{"id":"W4389953292","doi":"10.1161/circ.148.suppl_1.12433","title":"Abstract 12433: miR 187a-3p Prevents Septic-Induced Myocardial Dysfunction by Targeting the Inflammatory Cytokines TNFa and IL-6","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Sepsis; Inflammation; Tumor necrosis factor alpha; Septic shock; Ejection fraction; Cytokine; Cardiac function curve; Contractility; Heart failure; Circulatory system; Proinflammatory cytokine; Internal medicine; Perforation; Cardiology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752787,0.0005366975,0.0006549609,0.0002904069,0.0002083105,0.0003414431,0.0002667407,0.0004437554,0.004912177],"category_scores_gemma":[0.0001467878,0.0002102171,0.000368778,0.0001870123,0.0003841725,0.0002061681,0.0002556189,0.001111897,0.00158417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002022345,"about_ca_system_score_gemma":0.000446386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003375426,"about_ca_topic_score_gemma":0.0003542479,"domain_scores_codex":[0.9998415,0.00002304616,0.00001838189,0.00002744316,0.00005305875,0.00003663248],"domain_scores_gemma":[0.9999224,0.00001111348,0.00002728234,0.000007798129,0.00001071644,0.00002069242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002628229,0.000431135,0.0003670455,0.0003894577,0.00003784796,0.0001600461,0.00004450836,0.0001941903,0.9832758,0.0002854758,0.001931865,0.01025448],"study_design_scores_gemma":[0.0006186728,0.005401942,0.004559904,0.00004641732,0.0001401779,0.000831045,0.00007968541,0.001155688,0.9681115,0.0001767821,0.01885733,0.00002076729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684057,0.007281118,0.009495214,0.001140607,0.0008515863,0.0003546801,0.003801189,0.001462453,0.007207451],"genre_scores_gemma":[0.9772663,0.004007651,0.006407246,0.0005999855,0.0001282835,0.0004936234,0.003072784,0.0001496154,0.007874549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004912177,"threshold_uncertainty_score":0.01643282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03982286989316609,"score_gpt":0.2823734688679931,"score_spread":0.242550598974827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}