{"id":"W4389956165","doi":"10.1016/j.gene.2023.148099","title":"Intron retention is a mechanism of erythropoietin regulation in brain cell models","year":2023,"lang":"en","type":"article","venue":"Gene","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph; University of Calgary; Saint John Regional Hospital; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Intron; Biology; Erythropoietin; Erythropoiesis; Ischemia; Gene expression; Internal medicine; Endocrinology; Kidney; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003165359,0.0002979985,0.0002651542,0.0004049215,0.0003252023,0.0003959034,0.0005474323,0.0003299793,0.0006848678],"category_scores_gemma":[0.0001769571,0.0001326778,0.0002978074,0.000162739,0.0006313292,0.0003634861,0.0002314314,0.000541632,0.0002033209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003386613,"about_ca_system_score_gemma":0.0002520598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004862153,"about_ca_topic_score_gemma":0.0004010012,"domain_scores_codex":[0.9998621,0.00003275463,0.000008525818,0.00003981016,0.00003309196,0.00002356448],"domain_scores_gemma":[0.9998471,0.00003338894,0.00003587431,0.00003697709,0.00002277506,0.00002393786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001107138,0.00001641076,0.000438373,0.00002123665,0.000007567282,0.0001983214,0.00004297792,0.0002197554,0.9892672,0.007119266,0.00006143365,0.002496733],"study_design_scores_gemma":[0.00001454069,0.0001529985,0.002331221,0.000006341316,0.00002994348,0.0008098838,0.00005793667,0.004108423,0.9849263,0.004588582,0.002960711,0.00001297626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9238716,0.001810822,0.06702608,0.0004393433,0.00008802201,0.00003765823,0.0002297007,0.0003549625,0.006141848],"genre_scores_gemma":[0.989394,0.0004639224,0.007340739,0.00004609216,0.00001846682,0.00002515958,0.000121126,0.00004143552,0.002548876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006848678,"threshold_uncertainty_score":0.002457142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864106218495798,"score_gpt":0.2620447605037342,"score_spread":0.2434036983187762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}