{"id":"W4389956891","doi":"10.1161/circ.148.suppl_1.14843","title":"Abstract 14843: Unveiling the Phenotype of Smooth Muscle Foam Cells in Human Atherosclerotic Lesions: Insights From Bulk and Single Cell RNA Sequencing","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Foam cell; Cell; RNA; Phenotype; Transcriptome; Molecular biology; Macrophage; Gene; Gene expression; Medicine; Pathology; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009305222,0.0005500074,0.0007284696,0.0007872836,0.0005007299,0.0009421796,0.0003686352,0.0006727134,0.002111715],"category_scores_gemma":[0.0008918636,0.0002746243,0.0005038103,0.0007151364,0.0003388962,0.0003070766,0.0003891818,0.0007211039,0.001809785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002167366,"about_ca_system_score_gemma":0.0005867628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006451633,"about_ca_topic_score_gemma":0.001505467,"domain_scores_codex":[0.9994063,0.00007181365,0.00003639936,0.0002475994,0.0001857222,0.00005207005],"domain_scores_gemma":[0.9995721,0.0001214569,0.0000821437,0.00004908384,0.0001369233,0.00003835485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002123383,0.00003830016,0.003380358,0.0006229211,0.00005833932,0.0001335986,0.0002009436,0.0004245118,0.9693432,0.0003696982,0.002877552,0.02233816],"study_design_scores_gemma":[0.0001383859,0.0009751083,0.1444178,0.0003840828,0.0005246272,0.002470624,0.0004475723,0.02033327,0.738535,0.002727393,0.08890992,0.0001362194],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7449031,0.01295292,0.1761208,0.001740846,0.000577155,0.0003851817,0.05100641,0.004183328,0.008130218],"genre_scores_gemma":[0.6257477,0.007375652,0.2932776,0.001345253,0.0004476815,0.0009512106,0.06169727,0.002007958,0.007149704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002111715,"threshold_uncertainty_score":0.007064342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0327329064694757,"score_gpt":0.2250814717619105,"score_spread":0.1923485652924348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}