{"id":"W4389957014","doi":"10.1161/circ.148.suppl_1.17091","title":"Abstract 17091: ARO-APOC3, an Investigational RNAi Therapeutic, Silences APOC3 and Reduces Atherosclerosis-Associated Lipoproteins in Patients With Mixed Dyslipidemia: MUIR Study Results","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thornhill Medical (Canada); Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; Dyslipidemia; Internal medicine; Apolipoprotein B; Cholesterol; Endocrinology; Placebo; Triglyceride; Very low-density lipoprotein; Hypertriglyceridemia; Lipoprotein; Obesity; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001722676,0.0009667875,0.001434861,0.0003260719,0.000322422,0.0005553868,0.0006714982,0.0009202908,0.003669361],"category_scores_gemma":[0.0005255928,0.0002683562,0.001046191,0.0002612728,0.0004349561,0.000421213,0.0002297622,0.001684969,0.0006605117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003473799,"about_ca_system_score_gemma":0.000839158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004298483,"about_ca_topic_score_gemma":0.001164317,"domain_scores_codex":[0.9996521,0.000153789,0.00002851304,0.00005322891,0.00005970441,0.00005269494],"domain_scores_gemma":[0.9996626,0.00005428605,0.00007541581,0.00003141129,0.00004762189,0.000128539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5603988,0.0351096,0.005597594,0.002032107,0.003576394,0.000489898,0.0002086268,0.0008042908,0.2004567,0.0006162232,0.01131909,0.1793906],"study_design_scores_gemma":[0.4324639,0.4732524,0.04051977,0.000191699,0.004683409,0.001079193,0.0001236225,0.001938238,0.03197047,0.0004780845,0.01320455,0.00009473728],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827353,0.007472776,0.001141905,0.001053637,0.0001948908,0.001266051,0.002181026,0.0002841451,0.003670235],"genre_scores_gemma":[0.9819188,0.003250648,0.00369364,0.001859797,0.0002739468,0.001825916,0.002624557,0.00005151482,0.004501205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003669361,"threshold_uncertainty_score":0.01227522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0352706165480623,"score_gpt":0.2711196110287645,"score_spread":0.2358489944807022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}