{"id":"W4389957320","doi":"10.1161/circ.148.suppl_1.15168","title":"Abstract 15168: The Role of Mitochondrial Fission Factor (MFF) and Increased Midzone Mitochondrial Fission in Pulmonary Arterial Hypertension: Implications for Proliferation, Mitophagy, and Apoptosis","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Mitochondrial fission; FIS1; DNM1L; Cell biology; Mitophagy; Fission; Biology; Mitochondrion; Apoptosis; mitochondrial fusion; Mitochondrial DNA; Autophagy; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002223807,0.0003651544,0.0003408904,0.0004870384,0.000301771,0.0004137679,0.000304013,0.0006978828,0.008614587],"category_scores_gemma":[0.0001881161,0.0001356767,0.0002260073,0.0002568849,0.0003333633,0.0003160227,0.0002419623,0.000857993,0.001288931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002774616,"about_ca_system_score_gemma":0.0002316617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004965449,"about_ca_topic_score_gemma":0.0004010803,"domain_scores_codex":[0.9998472,0.0000182265,0.0000121452,0.00003348589,0.00006141097,0.0000275177],"domain_scores_gemma":[0.9998484,0.00002463579,0.00003889588,0.000006927632,0.00002851165,0.00005267905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002058442,0.0001713522,0.00281488,0.0006207378,0.00003311734,0.0007571455,0.00007872328,0.0000849672,0.9725721,0.0005620618,0.00177865,0.0184678],"study_design_scores_gemma":[0.0004617227,0.00262215,0.1796943,0.0002530652,0.0001483855,0.0134495,0.0002540488,0.002031339,0.7593549,0.001097233,0.04060152,0.0000317766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511437,0.02989324,0.004764054,0.003001155,0.0005116827,0.0001167572,0.002352035,0.0003275462,0.007889906],"genre_scores_gemma":[0.976481,0.006461306,0.003042728,0.0003180682,0.0002809368,0.0001102611,0.001791485,0.0000255054,0.01148876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008614587,"threshold_uncertainty_score":0.02881873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03230919885668584,"score_gpt":0.2893523900053919,"score_spread":0.2570431911487061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}