{"id":"W4389957377","doi":"10.1161/circ.148.suppl_1.18853","title":"Abstract 18853: Rescue of Pulmonary Hypertension-Induced Right Ventricular Failure by Silencing Snai1 Induces Alterations in Methylation Status of Critical Genes Regulating Endothelial-to-Mesenchymal-Transition and Fibrosis","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"SNAI1; Medicine; Fibrosis; Epithelial–mesenchymal transition; DNA methylation; Cancer research; Gene silencing; Internal medicine; Pathology; Gene; Biology; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166455,0.0003923141,0.000347923,0.0002324001,0.0001310809,0.0001761902,0.0002519445,0.0003131548,0.005056425],"category_scores_gemma":[0.00008990882,0.0001557195,0.0002958273,0.0001157038,0.0003072213,0.0002018569,0.0001847613,0.0007328804,0.000999783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660407,"about_ca_system_score_gemma":0.0002253246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005489814,"about_ca_topic_score_gemma":0.0007331996,"domain_scores_codex":[0.9998645,0.00001536453,0.00001559405,0.00003793334,0.00002995034,0.00003674088],"domain_scores_gemma":[0.9998989,0.000008369933,0.00003254277,0.00001215732,0.000007329015,0.00004074334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002151671,0.00004681067,0.0001422305,0.00005511118,0.000006061845,0.00004700522,0.00001346158,0.00004001314,0.997732,0.00007264686,0.000121164,0.001508165],"study_design_scores_gemma":[0.00009175857,0.001028952,0.006167331,0.00001703503,0.00003012913,0.0002607749,0.00006000362,0.000832007,0.9884524,0.00007465278,0.002977947,0.000006945492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865759,0.001971036,0.005798245,0.0003484135,0.0001658047,0.00006526044,0.001881776,0.0004719184,0.002721734],"genre_scores_gemma":[0.9861293,0.001045696,0.002040116,0.0001236802,0.00002592576,0.000123693,0.001591647,0.00007680663,0.008843062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005056425,"threshold_uncertainty_score":0.01691538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03049902899780611,"score_gpt":0.2981927261163924,"score_spread":0.2676936971185863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}