{"id":"W4389957441","doi":"10.1161/circ.148.suppl_1.15967","title":"Abstract 15967: Unravelling the Role of Deoxyhypusine Synthase-Mediated Hypusination of eIF5A in Pulmonary Arterial Hypertension","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"DHPS; Eukaryotic initiation factor; EIF4E; Cancer research; Medicine; Biology; Pharmacology; Cell biology; Biochemistry; Translation (biology); Pathology; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825411,0.0003216981,0.000216645,0.0001980293,0.0001245777,0.0002891719,0.0002164312,0.0003141042,0.001634768],"category_scores_gemma":[0.00008536368,0.0001227841,0.000240353,0.000123649,0.0002436743,0.000416153,0.000201423,0.0007561024,0.0004505444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001865846,"about_ca_system_score_gemma":0.0002509867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002336929,"about_ca_topic_score_gemma":0.0003717565,"domain_scores_codex":[0.9999542,0.000006571929,0.000005539389,0.000009401419,0.00001260492,0.00001171623],"domain_scores_gemma":[0.9999439,0.00000862638,0.00001656018,0.000003936975,0.000009270727,0.00001777034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004439973,0.00006367244,0.001122021,0.0005626749,0.0000231062,0.000248924,0.00003954914,0.0001755683,0.9812754,0.0006772555,0.0002512153,0.01511651],"study_design_scores_gemma":[0.000142809,0.001739585,0.04490749,0.0002266616,0.0001454783,0.002686502,0.0002508511,0.004471708,0.8922009,0.001314919,0.05188404,0.0000290004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9064868,0.07676496,0.009644229,0.002074489,0.0003022014,0.00007099254,0.0006469212,0.0001076792,0.003901706],"genre_scores_gemma":[0.9571653,0.03205372,0.005539232,0.0003915076,0.000225179,0.00004462652,0.0009397702,0.00001550819,0.003625276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001634768,"threshold_uncertainty_score":0.005468845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369824431423462,"score_gpt":0.2320609935345104,"score_spread":0.2183627492202758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}