{"id":"W4389957733","doi":"10.1161/circ.148.suppl_1.17120","title":"Abstract 17120: ARO-ANG3, an Investigational RNAi Therapeutic, Silences the Expression of ANGPTL3 and Decreases Atherogenic Lipoproteins in Patients With Mixed Dyslipidemia: ARCHES-2 Study Results","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; Dyslipidemia; Internal medicine; Apolipoprotein B; Endocrinology; Lipoprotein; Population; Steatosis; Cholesterol; Lipoprotein particle; PCSK9; Diabetes mellitus; Very low-density lipoprotein; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00153487,0.001040705,0.001570314,0.0002890815,0.0002571697,0.000583591,0.0005463788,0.0008101754,0.00412561],"category_scores_gemma":[0.0004351964,0.0003492604,0.00115635,0.0002260565,0.0004658661,0.0004678491,0.0002794141,0.001605902,0.0007561099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003715271,"about_ca_system_score_gemma":0.0008892615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004478391,"about_ca_topic_score_gemma":0.001869574,"domain_scores_codex":[0.9996458,0.000156164,0.00002883227,0.00006336669,0.00006169685,0.00004401901],"domain_scores_gemma":[0.999681,0.00004241886,0.00008041659,0.00002312652,0.00003500332,0.0001379695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7779847,0.02296137,0.007688991,0.001601576,0.003989316,0.0004130814,0.00009921426,0.0005413109,0.09474446,0.0003035418,0.007417756,0.08225468],"study_design_scores_gemma":[0.7247757,0.2181137,0.03165251,0.0001115179,0.003197023,0.0005644071,0.00005147051,0.001003188,0.01259061,0.0002210408,0.007669328,0.00004935164],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764956,0.008542895,0.001367095,0.001013235,0.0002123635,0.002149435,0.004429653,0.0002332833,0.005556464],"genre_scores_gemma":[0.9736577,0.004539195,0.003946379,0.00174241,0.0003687516,0.002854289,0.005376886,0.00005218133,0.007462309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00412561,"threshold_uncertainty_score":0.01380152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03283857070576879,"score_gpt":0.2743952725090944,"score_spread":0.2415567018033256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}