{"id":"W4389958047","doi":"10.1161/circ.148.suppl_1.11956","title":"Abstract 11956: Arumenamide-787 Suppresses Arrhythmogenesis Associated With the J Wave Syndrome as Well as Hypothermia","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Medicine; Internal medicine; Cardiology; Brugada syndrome; Quinidine; Afterdepolarization; Verapamil; Sodium channel blocker; Sudden cardiac death; Ajmaline; Cardiac transient outward potassium current; hERG; Repolarization; Sodium channel; Ranolazine; J wave; Hypothermia; Ventricular fibrillation; QT interval; Potassium channel; Sodium; Electrophysiology; Patch clamp; Calcium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009555587,0.0004165481,0.000445867,0.0001821624,0.0001335751,0.000165947,0.000326428,0.0003118541,0.003308709],"category_scores_gemma":[0.0001535015,0.00008625526,0.0002369107,0.0001084412,0.0002185725,0.0002299073,0.0001196158,0.000764253,0.0006418438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008214704,"about_ca_system_score_gemma":0.000210837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002254406,"about_ca_topic_score_gemma":0.0002941616,"domain_scores_codex":[0.9999514,0.00000675621,0.000007071479,0.000005874876,0.000008141226,0.00002083548],"domain_scores_gemma":[0.9999404,0.000008477771,0.00001317939,0.000006658392,0.000006944728,0.00002427177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003344659,0.001002311,0.0004090243,0.0003273972,0.00005325202,0.0003743746,0.00002921715,0.0001300984,0.9779418,0.0002213683,0.0007332828,0.01543316],"study_design_scores_gemma":[0.004579576,0.03452615,0.02072617,0.0000889776,0.0002738051,0.003032024,0.000144117,0.002019723,0.9228837,0.0002118718,0.01148302,0.00003088096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914152,0.003167881,0.0006204492,0.0001792343,0.0001486083,0.00006996496,0.0004364877,0.0001720605,0.00379008],"genre_scores_gemma":[0.9938186,0.001902806,0.0009305353,0.0001501496,0.00007223945,0.00006897016,0.0009078637,0.00001856923,0.002130236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003308709,"threshold_uncertainty_score":0.01106876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01474383011775121,"score_gpt":0.2375993208449413,"score_spread":0.22285549072719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}