{"id":"W4389958273","doi":"10.1111/hae.14912","title":"Landmark endorsement of a global registry: The European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP), publicly endorses World Federation of Hemophilia Gene Therapy Registry as global standard","year":2023,"lang":"en","type":"letter","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Medicine; Agency (philosophy); Patient registry; Family medicine; Russian federation; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008263947,0.0009034571,0.001335958,0.0008093254,0.006788685,0.007438494,0.002358298,0.1235127,0.01342075],"category_scores_gemma":[0.0297183,0.001059877,0.001727821,0.0007637707,0.003737913,0.003883528,0.002477326,0.06111724,0.01163982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006866766,"about_ca_system_score_gemma":0.02015144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02706907,"about_ca_topic_score_gemma":0.05582713,"domain_scores_codex":[0.9917536,0.001666406,0.0009381713,0.0009647702,0.002757374,0.001919668],"domain_scores_gemma":[0.9852419,0.006408126,0.0008542094,0.0005034626,0.004130013,0.002862253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003769848,0.00004173873,0.000413283,0.00002332861,0.00001172177,0.0008126143,0.0001150113,0.00003975679,0.0001995408,0.007407661,0.9876285,0.003269214],"study_design_scores_gemma":[0.0001346227,0.00005783356,0.001426769,0.0002036936,0.00003051092,0.00056128,0.0003203159,0.0005158367,0.0003195391,0.005997548,0.9903697,0.00006241025],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.0004674264,0.0003214744,0.0002639896,0.9724419,0.01486483,0.00003584503,0.0001228998,0.00005316014,0.01142841],"genre_scores_gemma":[0.002982074,0.0002903478,0.0003906577,0.9448452,0.0105643,0.00006001947,0.00006599592,0.00004789,0.04075346],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.1235127,"threshold_uncertainty_score":0.05382299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0897022501196842,"score_gpt":0.3583544054867289,"score_spread":0.2686521553670447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}