{"id":"W4389979608","doi":"10.1161/circ.148.suppl_1.211","title":"Abstract 211: Targeting the Mitochondrial Fission Protein Dynamin Related Protein 1 to Mitigate Oxygen Toxicity Following Cardiac Arrest","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Arrest and Resuscitation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Hyperoxia; DNM1L; Medicine; Mitochondrial fission; Hypoxia (environmental); Cardiopulmonary resuscitation; Oxygen toxicity; Anesthesia; Toxicity; Oxygen; Resuscitation; Internal medicine; Mitochondrion; Pharmacology; Biology; Lung; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223868,0.0003697496,0.0004619153,0.0001394237,0.0001701957,0.0002377506,0.0002016461,0.0003301373,0.001737048],"category_scores_gemma":[0.00007553946,0.00009107912,0.0001830612,0.00009289375,0.0002440556,0.000210573,0.000177241,0.000555342,0.0003285646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002138892,"about_ca_system_score_gemma":0.0002277667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001567888,"about_ca_topic_score_gemma":0.0002946286,"domain_scores_codex":[0.9999425,0.000007043015,0.000004646283,0.00001345381,0.00001285409,0.00001940285],"domain_scores_gemma":[0.9999387,0.000004715825,0.00002557721,0.000002852493,0.000007346178,0.00002068246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001521385,0.0002379454,0.0002725764,0.0002729905,0.00001962971,0.00008070031,0.00002033746,0.0001388589,0.9902927,0.0001406673,0.0005823115,0.006420024],"study_design_scores_gemma":[0.0005433426,0.008629604,0.009500962,0.00007695865,0.0001569751,0.0007778251,0.00009739422,0.001828127,0.968947,0.0002021171,0.009221297,0.00001845715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942858,0.001945044,0.001761196,0.0003307364,0.0001566307,0.00008854237,0.0003112352,0.00008708282,0.00103385],"genre_scores_gemma":[0.9895216,0.002558037,0.002433064,0.0002761221,0.00007636045,0.0001816845,0.0005569855,0.00001942661,0.004376739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737048,"threshold_uncertainty_score":0.005811036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176371129921786,"score_gpt":0.2622642599992219,"score_spread":0.250500548700004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}