{"id":"W4389989826","doi":"10.1126/scitranslmed.adg6822","title":"Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with <i>FOXP3</i> mutations","year":2023,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Stanford Maternal and Child Health Research Institute; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"FOXP3; Immunology; IL-2 receptor; T cell; Biology; Peripheral tolerance; Regulatory T cell; T-cell receptor; Autoimmunity; Primary immunodeficiency; Immune system; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424649,0.0003950478,0.0002459646,0.0007629204,0.0002030795,0.0002990564,0.00017579,0.000352396,0.00107714],"category_scores_gemma":[0.0003406628,0.0001675199,0.0002082017,0.0002756423,0.0002924583,0.0001891573,0.000220566,0.0002780675,0.0001503146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00010912,"about_ca_system_score_gemma":0.00005436848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003056967,"about_ca_topic_score_gemma":0.0003175366,"domain_scores_codex":[0.9998397,0.00001903774,0.00002063069,0.00006676742,0.00002599327,0.00002789089],"domain_scores_gemma":[0.9998022,0.00004547353,0.00007840751,0.00001883085,0.0000148658,0.00004020394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001588107,0.0001126241,0.318817,0.00008029085,0.00009965748,0.02015009,0.0006102011,0.0005170905,0.6372645,0.0002077286,0.0002234329,0.02032929],"study_design_scores_gemma":[0.00008953852,0.0008593908,0.8230839,0.00002573825,0.0002040669,0.1022165,0.0004006278,0.002576482,0.06874695,0.0002249801,0.001540442,0.00003140069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992788,0.0001033203,0.0003358856,0.00001108689,0.000001977653,0.000004666625,0.00004060186,0.00001972359,0.0002039553],"genre_scores_gemma":[0.9995615,0.00004590574,0.0002274992,0.00001620953,0.000004416268,0.000002957509,0.00005109887,0.000004973988,0.00008544598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107714,"threshold_uncertainty_score":0.003603399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075968142028631,"score_gpt":0.2337068331679151,"score_spread":0.2229471517476287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}