{"id":"W4389997018","doi":"10.1016/j.jacbts.2023.10.010","title":"Follicle-Stimulating Hormone Exacerbates Cardiovascular Disease in the Presence of Low or Castrate Testosterone Levels","year":2023,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Impact; Centre Hospitalier de l’Université de Montréal; Population Health Research Institute; McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Ferring Pharmaceuticals; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Medicine; Testosterone (patch); Androgen receptor; Prostate cancer; Follicle-stimulating hormone; Orchiectomy; Hormone; Androgen; LDL receptor; Agonist; Gonadotropin-releasing hormone agonist; Androgen deprivation therapy; Gonadotropin-releasing hormone; Gonadotropin-releasing hormone antagonist; Castration; Receptor; Lipoprotein; Luteinizing hormone; Cholesterol; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001345934,0.000116242,0.0002303046,0.0001667925,0.0001897141,0.00001843469,0.0002242026,0.00001816212,0.0000117172],"category_scores_gemma":[0.0005546676,0.00006687806,0.0001004276,0.00233732,0.0003983092,0.000197281,0.0000449072,0.0001000678,0.00001927924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002167445,"about_ca_system_score_gemma":0.0002622855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009640739,"about_ca_topic_score_gemma":0.00001920146,"domain_scores_codex":[0.9978932,0.00004696805,0.0002524957,0.0004321726,0.001079428,0.000295777],"domain_scores_gemma":[0.9990841,0.0002837574,0.00003224413,0.0003144696,0.0001670415,0.0001183473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001546721,0.0005859775,0.1970403,0.0004527496,0.000318964,0.0004627156,0.02221669,0.3400666,0.3606934,0.001340202,0.0002411614,0.07503446],"study_design_scores_gemma":[0.000528077,0.0001599075,0.9920353,0.00009674456,0.00004138054,0.000007318315,0.0004012385,0.005053458,0.001176669,0.0002618557,0.0001431249,0.00009488231],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928828,0.0006648811,0.0004280616,0.004958539,0.00004997792,0.0006113049,0.00003995655,0.00002720071,0.0003372091],"genre_scores_gemma":[0.9988176,0.00002026551,0.0008087342,0.00006320971,0.00009590374,0.00004237984,0.000003486031,0.00000681779,0.000141657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.794995,"threshold_uncertainty_score":0.2727208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07120735412507145,"score_gpt":0.3156344902615086,"score_spread":0.2444271361364372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}