{"id":"W4390016082","doi":"10.1097/hep.0000000000000728","title":"Seladelpar treatment reduces IL-31 and pruritus in patients with primary biliary cholangitis","year":2023,"lang":"en","type":"article","venue":"Hepatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"Ipsen; National Institute for Health and Care Research; GlaxoSmithKline","keywords":"Medicine; Gastroenterology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002250322,0.000223035,0.0005036237,0.000105849,0.0001387851,0.0001622558,0.0000772799,0.0001817514,0.001517732],"category_scores_gemma":[0.0004786254,0.00009784239,0.0002300287,0.00008810535,0.0001400235,0.0001212091,0.0001345282,0.0003753992,0.0002116481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001098879,"about_ca_system_score_gemma":0.0001152611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000175215,"about_ca_topic_score_gemma":0.0005473415,"domain_scores_codex":[0.9999074,0.0000370396,0.000008260862,0.000009707282,0.00001703269,0.00002062945],"domain_scores_gemma":[0.9998085,0.00005206667,0.00006130695,0.000007583061,0.00001573313,0.00005485325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.07108938,0.006308772,0.3090702,0.001557081,0.0008570799,0.002083293,0.0009544963,0.0008335394,0.3624355,0.0001280362,0.00305951,0.2416232],"study_design_scores_gemma":[0.004242584,0.07250299,0.8987064,0.00005881422,0.0004104579,0.003200738,0.0003730902,0.0005652881,0.01647095,0.0000469456,0.003406353,0.00001545888],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981419,0.001261238,0.00004519076,0.00006785101,0.000008011239,0.00002073891,0.00002659142,0.00001230171,0.0004162406],"genre_scores_gemma":[0.9991332,0.0003913859,0.0001112608,0.00007162292,0.00001656286,0.0000176142,0.00006834749,9.420726e-7,0.0001891716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001517732,"threshold_uncertainty_score":0.005077362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103383272001172,"score_gpt":0.244671832809062,"score_spread":0.2336380000890503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}