{"id":"W4390025172","doi":"10.1101/2023.12.18.23300129","title":"Low <i>IGFBP7</i> expression identifies a subset of breast cancers with favorable prognosis and sensitivity to IGF-1 receptor targeting with ganitumab: Data from I-SPY2 and SCAN-B","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Lunds Universitet; Cancerfonden","keywords":"Sensitivity (control systems); Breast cancer; Oncology; Cancer research; Expression (computer science); Internal medicine; Medicine; Receptor; Cancer; Computer science; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005571353,0.0003107965,0.0004305638,0.0002977713,0.0001203159,0.0004619886,0.0001343723,0.0002806791,0.002203465],"category_scores_gemma":[0.0005942958,0.00009662168,0.0003295512,0.000221638,0.0002790515,0.0001168789,0.0001197516,0.000425373,0.0006371752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002468937,"about_ca_system_score_gemma":0.0002071708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328121,"about_ca_topic_score_gemma":0.00118848,"domain_scores_codex":[0.9998702,0.00004437315,0.000009756536,0.00002222623,0.00002995916,0.00002354248],"domain_scores_gemma":[0.9996324,0.0001373533,0.00005535085,0.00003850722,0.00005939639,0.00007711868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03641285,0.000666961,0.3827983,0.0004801613,0.0007355353,0.001729285,0.0001537711,0.0007674162,0.4733106,0.0002295293,0.01238365,0.09033199],"study_design_scores_gemma":[0.0006493995,0.00540327,0.859766,0.00004216299,0.0006578987,0.007917309,0.00017833,0.002071487,0.1068377,0.0003885661,0.01605277,0.00003516264],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872892,0.005911857,0.0009744078,0.000683322,0.00009405948,0.00003104842,0.001808476,0.00008538824,0.00312222],"genre_scores_gemma":[0.9918482,0.001319913,0.0008409376,0.000293532,0.00004156295,0.00001363412,0.003986652,0.00003047917,0.001624965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002203465,"threshold_uncertainty_score":0.007371306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956050020022482,"score_gpt":0.2477825929230228,"score_spread":0.228222092722798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}