{"id":"W4390034971","doi":"10.1101/2023.12.20.572033","title":"Multimodal analysis unveils tumor microenvironment heterogeneity linked to immune activity and evasion","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Oesterreichische Nationalbank; Österreichischen Akademie der Wissenschaften; Rosetrees Trust; European Commission; National Institute for Health and Care Research; Universität Innsbruck; Austrian Science Fund; University College London; Cancer Research UK; Wellcome Trust","keywords":"Immunotherapy; Immune system; Tumor microenvironment; Biology; Transcriptome; Cancer immunotherapy; Computational biology; Immune checkpoint; Cancer; Cancer research; Immunology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002572997,0.0002373423,0.0003803765,0.0004740102,0.0001488972,0.0006181013,0.0001330626,0.0002775108,0.0009152902],"category_scores_gemma":[0.0002357367,0.0001541536,0.0002308811,0.0003967518,0.0004613156,0.0003972659,0.0003164297,0.00049863,0.0002210177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002773606,"about_ca_system_score_gemma":0.0001951614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003981918,"about_ca_topic_score_gemma":0.0006037261,"domain_scores_codex":[0.9998745,0.00001499071,0.000005374115,0.00004906185,0.00003375801,0.00002235381],"domain_scores_gemma":[0.999885,0.00003825024,0.00003009247,0.00001678261,0.00001664991,0.0000133024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005439009,0.000007707022,0.003763952,0.00005868387,0.00001469381,0.000044741,0.0000313058,0.001748749,0.9898738,0.0003775406,0.00008424334,0.00394012],"study_design_scores_gemma":[0.0000134515,0.000156059,0.104021,0.00002577306,0.00008855095,0.0004217626,0.000453158,0.08321983,0.8020661,0.00537748,0.004112056,0.00004471745],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9443451,0.0009096599,0.05159844,0.0001802695,0.00002099648,0.00001724539,0.001367366,0.0002316998,0.001329144],"genre_scores_gemma":[0.9861611,0.0004458886,0.01202126,0.00007127295,0.00001949102,0.00002499581,0.0006300653,0.00005276717,0.0005730888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009152902,"threshold_uncertainty_score":0.00306195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.016431636549159,"score_gpt":0.2272592315131581,"score_spread":0.2108275949639991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}