{"id":"W4390046003","doi":"10.1126/science.adh1859","title":"Molecular determinants of ligand efficacy and potency in GPCR signaling","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of Neurological Disorders and Stroke; Novo Nordisk Fonden; Wellcome Trust","keywords":"Allosteric regulation; G protein-coupled receptor; Heterotrimeric G protein; Signal transduction; Ligand (biochemistry); Receptor; G protein; Functional selectivity; Drug discovery; Chemistry; Cell signaling; Biology; Cell biology; Computational biology; Biochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004645621,0.00005743304,0.00007903615,0.00009320304,0.00004845751,0.00001540345,0.0001568598,0.00003788789,0.00000317124],"category_scores_gemma":[0.0001186159,0.00005269745,0.0000166202,0.0003786406,0.0001340608,0.000004700016,0.0001069165,0.00002997938,0.000002182575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003241983,"about_ca_system_score_gemma":0.00005903097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001010349,"about_ca_topic_score_gemma":0.00000378522,"domain_scores_codex":[0.9993006,0.00001207995,0.0001234243,0.0002406736,0.0001359268,0.0001873183],"domain_scores_gemma":[0.9997504,0.000007187868,0.00003644808,0.0001250473,0.00003455382,0.00004636314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005456135,0.000006901828,0.00221497,0.000007752144,6.865756e-7,0.000005969025,0.00006584464,0.0001949299,0.9931226,0.00003209779,0.000001375913,0.004341393],"study_design_scores_gemma":[0.0001761625,0.0000926404,0.00496564,0.00002231965,0.000001522816,0.000003331797,0.00006720595,0.0006626375,0.9936896,0.0002006917,0.00005105848,0.00006719473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993337,0.0002381161,0.0002002375,0.0000132876,0.00006390195,0.00006422876,0.000001223422,0.000004871249,0.00008036682],"genre_scores_gemma":[0.999491,0.00005028009,0.0003821026,0.00002119481,0.00001339865,0.000002332793,0.000001200005,0.00000491537,0.00003361286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004274199,"threshold_uncertainty_score":0.214894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115326764042404,"score_gpt":0.2754003867220792,"score_spread":0.2638677103178388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}