{"id":"W4390046003","doi":"10.1126/science.adh1859","title":"Molecular determinants of ligand efficacy and potency in GPCR signaling","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of Neurological Disorders and Stroke; Novo Nordisk Fonden; Wellcome Trust","keywords":"Allosteric regulation; G protein-coupled receptor; Heterotrimeric G protein; Signal transduction; Ligand (biochemistry); Receptor; G protein; Functional selectivity; Drug discovery; Chemistry; Cell signaling; Biology; Cell biology; Computational biology; Biochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007837225,0.0002028599,0.0004637493,0.0002118749,0.0002570731,0.001000114,0.0003695826,0.0004931274,0.001314683],"category_scores_gemma":[0.001217504,0.0002512706,0.0002329417,0.0001737965,0.0008191086,0.0008117715,0.0003892042,0.0007999696,0.0003997704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004614402,"about_ca_system_score_gemma":0.0002855647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001927761,"about_ca_topic_score_gemma":0.0002664875,"domain_scores_codex":[0.9995778,0.0001127683,0.00002800113,0.00008669429,0.0001301393,0.00006456325],"domain_scores_gemma":[0.9995469,0.0002335273,0.0000800314,0.00004481484,0.00003572916,0.00005887503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002168049,0.00005553358,0.00106105,0.00009105688,0.00001068576,0.00009833228,0.00004280745,0.001993261,0.9746961,0.01487362,0.0001023058,0.006758356],"study_design_scores_gemma":[0.00007519659,0.0005898126,0.008268861,0.00002005276,0.00004408568,0.0004637159,0.0001256571,0.0210758,0.9532686,0.01282228,0.003194799,0.0000510949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563133,0.003041901,0.0288402,0.0009009946,0.0000633308,0.00004893134,0.0002400574,0.0001615125,0.0103897],"genre_scores_gemma":[0.9963007,0.0006119171,0.002418026,0.0001371925,0.00001904467,0.00001433179,0.00005068674,0.00001467862,0.0004333902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001314683,"threshold_uncertainty_score":0.004397988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115326764042404,"score_gpt":0.2754003867220792,"score_spread":0.2638677103178388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}