{"id":"W4390046443","doi":"10.1073/pnas.2306863120","title":"Identification of a muropeptide precursor transporter from gut microbiota and its role in preventing intestinal inflammation","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","keywords":"Peptidoglycan; Biology; ATP-binding cassette transporter; Immune system; Secretion; Microbiology; Intestinal mucosa; Inflammation; Transporter; Cell biology; Biochemistry; Immunology; Enzyme; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001291371,0.0002144561,0.0003244959,0.0001606503,0.00009379857,0.0002997146,0.0001315103,0.0003097582,0.0008776263],"category_scores_gemma":[0.0001813804,0.00008128444,0.0002339934,0.0001602769,0.0001227852,0.0002386695,0.0001731164,0.0004051232,0.0003872158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001393819,"about_ca_system_score_gemma":0.000188195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002149158,"about_ca_topic_score_gemma":0.0002708454,"domain_scores_codex":[0.9999319,0.00001340935,0.000005438331,0.00001234002,0.00002024854,0.00001657069],"domain_scores_gemma":[0.999922,0.00001459293,0.00001931546,0.000008493525,0.00001513035,0.00002042027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006658326,0.00001624368,0.0002130802,0.00002865144,0.00000255218,0.00004261682,0.000005341369,0.00002097218,0.9977922,0.00004809796,0.00000964315,0.001754089],"study_design_scores_gemma":[0.00001775303,0.0005645457,0.005826532,0.00001057814,0.00002775335,0.0005510537,0.00004219311,0.0006532912,0.9895353,0.000060463,0.002706366,0.000004248003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860731,0.002951464,0.009184319,0.0003403687,0.00002626183,0.00006050937,0.000276279,0.00006957409,0.001018063],"genre_scores_gemma":[0.9803314,0.002521525,0.01357501,0.0001341766,0.0000222073,0.0000371411,0.0009482921,0.00002193025,0.002408392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008776263,"threshold_uncertainty_score":0.002935946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02476061916609783,"score_gpt":0.2811826384749332,"score_spread":0.2564220193088354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}