{"id":"W4390048756","doi":"10.1007/s13318-023-00873-1","title":"Pharmacokinetics of Long-Acting Methylphenidate: Formulation Differences, Bioequivalence, Interchangeability","year":2023,"lang":"en","type":"review","venue":"European Journal of Drug Metabolism and Pharmacokinetics","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Bioequivalence; Interchangeability; Pharmacokinetics; Medicine; Pharmacology; Methylphenidate; Computer science; Clinical psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002576946,0.0006117664,0.002717782,0.0007921569,0.00007433755,0.00005551607,0.0004191997,0.00009513575,0.0001850533],"category_scores_gemma":[0.0003753495,0.0004668317,0.0008261038,0.0007933817,0.0001818299,0.0002296592,0.0003055568,0.001302652,0.00002699139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003805596,"about_ca_system_score_gemma":0.000205149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003523781,"about_ca_topic_score_gemma":5.968022e-7,"domain_scores_codex":[0.9946229,0.00151471,0.002331189,0.0004002327,0.0007582,0.0003727819],"domain_scores_gemma":[0.9953464,0.000560783,0.002763866,0.0003613324,0.0006268114,0.0003407651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001101912,0.0002717895,0.000270429,0.01905604,0.001030059,0.0002109559,0.0005693723,0.000006122794,0.0002315187,0.00001563856,0.0002973207,0.9779305],"study_design_scores_gemma":[0.004410082,0.0003060863,0.003868385,0.01546748,0.02465475,0.0009572015,0.000505432,0.0002127006,0.0002073195,0.000025922,0.9484976,0.000887013],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02575216,0.9704976,0.001099469,0.0000875853,0.001330954,0.0006833421,0.0001337176,0.00004308124,0.0003720703],"genre_scores_gemma":[0.03602169,0.9614393,0.0009487068,0.00004164643,0.0009564207,0.000002941168,0.00004848186,0.0001614657,0.0003793992],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9770436,"threshold_uncertainty_score":0.9997783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.159397126437488,"score_gpt":0.4050652895116338,"score_spread":0.2456681630741458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}