{"id":"W4390051577","doi":"10.2217/fon-2023-0649","title":"Prostate-Specific Antigen (PSA) Decline with Apalutamide Therapy is Associated with Longer Survival and Improved Outcomes in Individuals with Metastatic Prostate Cancer: A Plain Language Summary of the TITAN Study","year":2023,"lang":"en","type":"article","venue":"Future Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Medicine; Placebo; Prostate cancer; Androgen deprivation therapy; Prostate-specific antigen; Internal medicine; Oncology; Prostatectomy; Post-hoc analysis; Urology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007305084,0.0003147209,0.0008979994,0.0002451988,0.0001087884,0.00002509532,0.0001634766,0.000100327,0.00003934724],"category_scores_gemma":[0.0000247676,0.0001418165,0.00004405745,0.001154559,0.0003151145,0.000079732,0.00009669377,0.0004089192,0.000001564666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002393558,"about_ca_system_score_gemma":0.0006372387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000571465,"about_ca_topic_score_gemma":0.01048951,"domain_scores_codex":[0.9977974,0.0003033236,0.0003421459,0.0004667323,0.0005571342,0.000533321],"domain_scores_gemma":[0.9988343,0.0002814804,0.0002530919,0.0003495137,0.0001690915,0.0001125939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005566367,0.0009829163,0.9657058,0.00006391756,0.001451208,0.0006227362,0.01991309,0.000006699801,0.001268609,0.000006239917,0.0003072374,0.004105177],"study_design_scores_gemma":[0.02408536,0.0084048,0.9431115,0.0001849959,0.0001639409,0.00001603607,0.02181913,0.00002093513,0.0007981404,0.00001528186,0.001181068,0.0001988512],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876887,0.001930415,5.100688e-7,0.005713557,0.00009156568,0.004029592,0.0003507881,0.0000561421,0.000138795],"genre_scores_gemma":[0.9948844,0.001783252,0.0001364194,0.0002693895,0.0000584728,0.0005455986,0.0001501528,0.00006583731,0.002106475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02259434,"threshold_uncertainty_score":0.5853395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02774283542044691,"score_gpt":0.3413039054678971,"score_spread":0.3135610700474502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}