{"id":"W4390051577","doi":"10.2217/fon-2023-0649","title":"Prostate-Specific Antigen (PSA) Decline with Apalutamide Therapy is Associated with Longer Survival and Improved Outcomes in Individuals with Metastatic Prostate Cancer: A Plain Language Summary of the TITAN Study","year":2023,"lang":"en","type":"article","venue":"Future Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Medicine; Placebo; Prostate cancer; Androgen deprivation therapy; Prostate-specific antigen; Internal medicine; Oncology; Prostatectomy; Post-hoc analysis; Urology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0148318,0.001021544,0.002855189,0.0008801994,0.0002987566,0.002190919,0.000773253,0.001040893,0.005105788],"category_scores_gemma":[0.02078684,0.0003479026,0.009278076,0.001208078,0.0004844661,0.0008825366,0.0007209394,0.001574095,0.0007687397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006492652,"about_ca_system_score_gemma":0.001601175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001930187,"about_ca_topic_score_gemma":0.003639599,"domain_scores_codex":[0.9928645,0.004113905,0.001298678,0.0004425126,0.001087383,0.0001930212],"domain_scores_gemma":[0.9777975,0.0120673,0.004872379,0.001177968,0.003527036,0.0005577472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.2032764,0.001475045,0.134911,0.1485877,0.1831612,0.001093399,0.001353782,0.001419591,0.006872252,0.001309634,0.07255553,0.2439845],"study_design_scores_gemma":[0.05702733,0.03622884,0.5274988,0.02379353,0.2633185,0.001195626,0.0009303708,0.001129032,0.002453705,0.00169364,0.08413909,0.0005914859],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.3355243,0.5721233,0.005188972,0.02415942,0.00943506,0.005074598,0.03372154,0.0002861841,0.01448666],"genre_scores_gemma":[0.7425886,0.1673855,0.008300345,0.02600924,0.02004883,0.005042621,0.02168285,0.0002933397,0.008648775],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.0148318,"threshold_uncertainty_score":0.078439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02774283542044691,"score_gpt":0.3413039054678971,"score_spread":0.3135610700474502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}