{"id":"W4390052775","doi":"10.1186/s13063-023-07860-6","title":"Effect of intranasal insulin administration on postoperative delirium prevention in elderly cardiac surgery patients: study protocol for a multicenter, double-blind, randomized, controlled trial","year":2023,"lang":"en","type":"article","venue":"Trials","topic":"Intensive Care Unit Cognitive Disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"Japan Society for the Promotion of Science; University of Tsukuba","keywords":"Medicine; Delirium; Randomized controlled trial; Anesthesia; Cardiac surgery; Postoperative cognitive dysfunction; Clinical trial; Surgery; Cardiopulmonary bypass; Hypoglycemia; Internal medicine; Insulin; Intensive care medicine; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01616754,0.0003324647,0.004436029,0.0007290684,0.00005214555,0.00002851093,0.00006190499,0.0001676437,0.00003733465],"category_scores_gemma":[0.1110904,0.0002253411,0.001391012,0.0004139901,0.00007553337,0.00009932699,0.00001547846,0.0001941052,0.0000130626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008876419,"about_ca_system_score_gemma":0.0003398457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004152327,"about_ca_topic_score_gemma":0.00003418109,"domain_scores_codex":[0.9895897,0.006775617,0.002435166,0.0004075744,0.0005068104,0.000285115],"domain_scores_gemma":[0.9749765,0.01839566,0.0009393137,0.000215349,0.005399837,0.00007334286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9884527,0.002419717,0.0003878468,0.0002013438,0.0009824405,0.000008155954,0.0005706319,0.000003967346,0.0001655153,0.0000115177,0.0008870075,0.005909134],"study_design_scores_gemma":[0.9550361,0.03411944,0.0001205207,0.0004634607,0.0009982254,1.540025e-7,0.0009250051,0.0000697935,0.008049787,0.0000127789,0.0000425047,0.0001622394],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.4925166,0.00000356884,0.00003549604,0.0002346637,0.0004752271,0.5065996,0.00003027108,0.00003033134,0.00007420607],"genre_scores_gemma":[0.4849072,0.00000341259,0.000006288485,0.00014862,0.0001313986,0.5144562,0.0002691874,0.00002439423,0.00005334945],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.09492289,"threshold_uncertainty_score":0.9189144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08612820920993572,"score_gpt":0.4414038736924402,"score_spread":0.3552756644825045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}