{"id":"W4390053220","doi":"10.3390/cells13010023","title":"NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"China Scholarship Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Nierstichting; ZonMw; Fundação de Amparo à Pesquisa do Estado de São Paulo; Amsterdam University Medical Centers","keywords":"Fibrosis; Macrophage polarization; Kidney; Biology; Inflammation; Pathology; Nephropathy; Macrophage; Cancer research; M2 Macrophage; Kidney disease; Medicine; Endocrinology; Immunology; In vitro; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007267023,0.0001210837,0.0001889052,0.0001450061,0.00004849832,0.00001956052,0.00004776845,0.00008115362,0.0001989574],"category_scores_gemma":[0.00005240184,0.000113947,0.00004675498,0.0003983423,0.00006447589,0.0001064272,0.0000666875,0.0001131317,0.0001269894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001986592,"about_ca_system_score_gemma":0.0002483674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003521559,"about_ca_topic_score_gemma":0.000005356876,"domain_scores_codex":[0.9991096,0.00003719273,0.0001699651,0.0002644444,0.0001502163,0.0002685327],"domain_scores_gemma":[0.99953,0.00005002459,0.000054385,0.0001660763,0.00002630599,0.0001732561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001060345,0.00007531861,0.0286302,0.0004496677,0.00004841795,0.0001532006,0.000593739,0.0000410023,0.9582418,0.00003546509,0.00194131,0.00968389],"study_design_scores_gemma":[0.004058552,0.0003399833,0.6197848,0.0006220472,0.0001434586,0.000006756655,0.0002723179,0.002384509,0.3690921,0.0007635106,0.002260693,0.0002713299],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974384,0.001399076,0.00001538661,0.00009311021,0.0001117196,0.0003130332,0.00005170416,0.00005848437,0.0005190516],"genre_scores_gemma":[0.997299,0.0002031374,0.00005685857,0.0001448758,0.0001616514,0.0000215129,0.0001595677,0.0000211415,0.001932326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5911546,"threshold_uncertainty_score":0.4646623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007605292224706609,"score_gpt":0.2482303819050916,"score_spread":0.240625089680385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}