{"id":"W4390053220","doi":"10.3390/cells13010023","title":"NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"China Scholarship Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Nierstichting; ZonMw; Fundação de Amparo à Pesquisa do Estado de São Paulo; Amsterdam University Medical Centers","keywords":"Fibrosis; Macrophage polarization; Kidney; Biology; Inflammation; Pathology; Nephropathy; Macrophage; Cancer research; M2 Macrophage; Kidney disease; Medicine; Endocrinology; Immunology; In vitro; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004282246,0.0003904475,0.0007517313,0.0002703201,0.0002653277,0.000362031,0.0003867713,0.0005579205,0.002257814],"category_scores_gemma":[0.0002266884,0.0001563895,0.0003850802,0.0002046241,0.0004585089,0.0002936753,0.0002298253,0.001039508,0.0004199895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001706691,"about_ca_system_score_gemma":0.0004204305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003050405,"about_ca_topic_score_gemma":0.0004647162,"domain_scores_codex":[0.9997603,0.00004899457,0.00003154179,0.00003293905,0.00004675336,0.00007943934],"domain_scores_gemma":[0.9997751,0.00001998608,0.0000723212,0.00002733772,0.00002605995,0.00007912378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002799597,0.0008352979,0.000719085,0.0003381655,0.0000314599,0.0001096685,0.00007019449,0.000126769,0.9896331,0.0001840702,0.0002814031,0.004871103],"study_design_scores_gemma":[0.0009060794,0.006241501,0.01530915,0.00009234371,0.0001140741,0.0009200681,0.0002166677,0.001478888,0.9677022,0.0002442189,0.006757515,0.00001734301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937982,0.002345665,0.00205483,0.0003332613,0.0001041785,0.00006662188,0.0002426371,0.0001608065,0.0008939121],"genre_scores_gemma":[0.9936672,0.001324321,0.00167992,0.000149151,0.00004010698,0.0001000227,0.0004254125,0.00003835021,0.00257551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002257814,"threshold_uncertainty_score":0.00755316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007605292224706609,"score_gpt":0.2482303819050916,"score_spread":0.240625089680385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}