{"id":"W4390055438","doi":"10.1002/mds.29698","title":"Lysosomal Polygenic Burden Drives Cognitive Decline in Parkinson's Disease with Low Alzheimer Risk","year":2023,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Helse Sør-Øst RHF; National Institutes of Health; Parkinson Vereniging; Little Family Foundation; American Brain Foundation; Michael J. Fox Foundation for Parkinson's Research; Nasjonalforeningen for Folkehelsen; American Parkinson Disease Association; Lewy Body Dementia Association; Demensförbundet; U.S. Department of Defense","keywords":"Neuropathology; Parkinson's disease; Disease; Cognitive decline; Cognition; Alzheimer's disease; Biomarker; Dementia; Medicine; Cohort; Oncology; Psychology; Psychiatry; Internal medicine; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001112196,0.0004376182,0.000459535,0.0008137666,0.0005113715,0.001134928,0.0003430877,0.0004501349,0.002458166],"category_scores_gemma":[0.005208977,0.0002780521,0.0006206873,0.0008215827,0.000533496,0.000463015,0.0009242706,0.0006261324,0.0002338324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004090167,"about_ca_system_score_gemma":0.0006220467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008611558,"about_ca_topic_score_gemma":0.008409863,"domain_scores_codex":[0.9994887,0.0001832884,0.000045371,0.0001518151,0.00006890596,0.00006194937],"domain_scores_gemma":[0.9968166,0.0008877481,0.001570495,0.0002770615,0.0001946341,0.0002535255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000378257,0.00003114795,0.9956098,0.00001731421,0.0001828015,0.0001886469,0.00008029099,0.0001484864,0.0005880848,0.0001077105,0.000125581,0.002542025],"study_design_scores_gemma":[0.00001132508,0.00007743706,0.9974516,0.00001404295,0.0001165258,0.0005257225,0.00007861466,0.0009801672,0.0001530074,0.0004870907,0.00009933732,0.00000518085],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980401,0.0006688019,0.0003755158,0.0001438926,0.000005812254,0.000005242053,0.0002371705,0.00001671098,0.0005067692],"genre_scores_gemma":[0.999459,0.000120532,0.0001344116,0.00001753241,0.000006783077,0.000002292538,0.0001452464,0.000002947386,0.0001112832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008611558,"threshold_uncertainty_score":0.01712286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0114427270315432,"score_gpt":0.2616649180237206,"score_spread":0.2502221909921774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}