{"id":"W4390055438","doi":"10.1002/mds.29698","title":"Lysosomal Polygenic Burden Drives Cognitive Decline in Parkinson's Disease with Low Alzheimer Risk","year":2023,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Helse Sør-Øst RHF; National Institutes of Health; Parkinson Vereniging; Little Family Foundation; American Brain Foundation; Michael J. Fox Foundation for Parkinson's Research; Nasjonalforeningen for Folkehelsen; American Parkinson Disease Association; Lewy Body Dementia Association; Demensförbundet; U.S. Department of Defense","keywords":"Neuropathology; Parkinson's disease; Disease; Cognitive decline; Cognition; Alzheimer's disease; Biomarker; Dementia; Medicine; Cohort; Oncology; Psychology; Psychiatry; Internal medicine; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001384174,0.0003525146,0.0003502466,0.0003220229,0.0001312652,0.00003078098,0.0001094806,0.00006197391,0.0002760029],"category_scores_gemma":[0.00006057242,0.0002870314,0.0001602965,0.0006349278,0.00009764999,0.0001133375,0.000107192,0.0001555912,0.0002604599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007388618,"about_ca_system_score_gemma":0.0001519455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000646491,"about_ca_topic_score_gemma":0.0007326725,"domain_scores_codex":[0.9978684,0.00008186263,0.0002715556,0.0006309303,0.0005464872,0.0006007413],"domain_scores_gemma":[0.9990065,0.00007815892,0.0001153897,0.000318894,0.00004595126,0.0004351001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002018688,0.001025971,0.9719817,0.00004480212,0.0009172495,0.0005792961,0.0003306607,0.0001702003,0.00006514524,0.0000680447,0.0003569622,0.02244125],"study_design_scores_gemma":[0.009320224,0.0004632763,0.9773225,0.000217688,0.000934945,3.126195e-7,0.001171033,0.001975497,0.0002160057,0.004584428,0.003451839,0.0003423195],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937469,0.001506554,0.0001597257,0.002330828,0.00009180679,0.001186813,0.0002322854,0.0001915006,0.0005535365],"genre_scores_gemma":[0.9953831,0.001245698,0.0001324592,0.001859535,0.00006985853,0.0004078043,0.0004281887,0.0000676238,0.0004057262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02209893,"threshold_uncertainty_score":0.9999582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0114427270315432,"score_gpt":0.2616649180237206,"score_spread":0.2502221909921774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}