{"id":"W4390059913","doi":"10.3390/cancers16010052","title":"Infliximab, a Monoclonal Antibody against TNF-α, Inhibits NF-κB Activation, Autotaxin Expression and Breast Cancer Metastasis to Lungs","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Science and Engineering Research Board; Canadian Institutes of Health Research; University of Alberta","keywords":"Autotaxin; Cancer research; Tumor necrosis factor alpha; Metastasis; Tumor progression; Proinflammatory cytokine; Medicine; Cancer; Infliximab; Tumor microenvironment; Breast cancer; Chemokine; Immunology; Biology; Immune system; Lysophosphatidic acid; Inflammation; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195668,0.0002939252,0.0002863469,0.0002271508,0.000116023,0.0001632801,0.0001383507,0.0002511487,0.0008439714],"category_scores_gemma":[0.000101383,0.0001162681,0.0002415027,0.0001411765,0.00011435,0.0001170253,0.0000659073,0.0005248762,0.0003133439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681513,"about_ca_system_score_gemma":0.000122234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003262264,"about_ca_topic_score_gemma":0.0007046769,"domain_scores_codex":[0.9998912,0.00002468252,0.00001184834,0.0000144148,0.00002958929,0.00002839724],"domain_scores_gemma":[0.9999421,0.00001168112,0.0000184792,0.000006057679,0.000007424077,0.00001437631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001811952,0.000106087,0.0001962358,0.0000599361,0.000008726088,0.00004928085,0.00001000288,0.00004853741,0.9942588,0.00002956094,0.0001286497,0.004922988],"study_design_scores_gemma":[0.000321951,0.003796949,0.01245739,0.00002365494,0.00006110808,0.001888638,0.00002605741,0.001129059,0.9689643,0.00005528056,0.01126892,0.000006784575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784639,0.01622101,0.002337655,0.0002867643,0.0001232551,0.00005624721,0.0001833682,0.0001223641,0.002205512],"genre_scores_gemma":[0.9894627,0.005306935,0.001782658,0.0001290129,0.00003853373,0.00005003666,0.0005000086,0.00001220195,0.002717993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008439714,"threshold_uncertainty_score":0.002823353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01185383469166146,"score_gpt":0.2874682338148159,"score_spread":0.2756143991231544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}