{"id":"W4390062308","doi":"10.1101/2023.12.20.572623","title":"Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; East China Institute of Technology; European Commission; Society for Endocrinology; University of Alberta; UK Research and Innovation; Wellcome Trust","keywords":"Proinflammatory cytokine; Gene isoform; Nonsense-mediated decay; Nonsense; Cell biology; RNA; Messenger RNA; Biology; Chemistry; Immunology; Genetics; Gene; Inflammation; RNA splicing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002514305,0.0004466942,0.0003289817,0.0001709769,0.0001300749,0.0003471531,0.0001245216,0.0002200237,0.001532534],"category_scores_gemma":[0.0001384235,0.0001234664,0.0004414204,0.0001533243,0.0001759223,0.0001638142,0.0001637569,0.000597944,0.000457959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515129,"about_ca_system_score_gemma":0.0001808123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819257,"about_ca_topic_score_gemma":0.0002606488,"domain_scores_codex":[0.9997844,0.00003923165,0.00003112558,0.00005207997,0.00004410992,0.00004912667],"domain_scores_gemma":[0.9998286,0.00003946545,0.00005431692,0.00002263254,0.00002415191,0.00003079182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000118783,0.00001679427,0.00006230024,0.00002740488,0.000002455155,0.00001572191,0.0000070038,0.00001293704,0.9992821,0.00002150404,0.0000147678,0.0004182116],"study_design_scores_gemma":[0.00001646676,0.0001843651,0.001441511,0.000005165283,0.000008852561,0.00009355391,0.00001633748,0.000258636,0.9968171,0.00002349962,0.001132873,0.000001707461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985241,0.003479429,0.008463022,0.0001713104,0.00009547569,0.00005919441,0.0008622899,0.0001410778,0.001487206],"genre_scores_gemma":[0.9854391,0.002687753,0.007150252,0.0001958755,0.00003398953,0.0001142776,0.001430808,0.00007307351,0.002874936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001532534,"threshold_uncertainty_score":0.005126834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772455169518938,"score_gpt":0.2327154221410135,"score_spread":0.2149908704458241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}