{"id":"W4390062515","doi":"10.1172/jci.insight.170055","title":"Scaffold protein SH3BP2 signalosome is pivotal for immune activation in nephrotic syndrome","year":2023,"lang":"en","type":"article","venue":"JCI Insight","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Ottawa Hospital; Princess Margaret Cancer Centre; University of Ottawa","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Rare Diseases Clinical Research Network; U.S. Department of Veterans Affairs; University of California, San Diego; Nephcure Foundation; National Center for Advancing Translational Sciences; Foundation for the National Institutes of Health","keywords":"Minimal change disease; Focal segmental glomerulosclerosis; Nephrin; Nephrotic syndrome; Internal medicine; Podocyte; Biology; Endocrinology; Medicine; Cell biology; Cancer research; Glomerulonephritis; Kidney; Proteinuria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243652,0.0003748213,0.0002123892,0.000538151,0.0002278225,0.0002849121,0.0001458186,0.0003144062,0.001815592],"category_scores_gemma":[0.0001748463,0.0001246075,0.0003091239,0.0002552227,0.000247671,0.000144132,0.0003413178,0.0003845609,0.0003336943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002213514,"about_ca_system_score_gemma":0.0001828344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009761021,"about_ca_topic_score_gemma":0.0009922255,"domain_scores_codex":[0.999882,0.00001995469,0.00001281119,0.00002980679,0.00003429003,0.00002119265],"domain_scores_gemma":[0.99989,0.000009682981,0.00004254076,0.000005574539,0.0000150636,0.00003724358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001937642,0.00006637288,0.07640477,0.0003399787,0.000178628,0.004270016,0.0001324497,0.0003023493,0.8974772,0.0005037473,0.001697895,0.01668885],"study_design_scores_gemma":[0.0001469322,0.0003482026,0.7991853,0.00009541807,0.0003198674,0.0141969,0.0002748508,0.003355191,0.1705707,0.001236321,0.01023831,0.00003204119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913088,0.00443565,0.001500696,0.0002749258,0.00003635653,0.00001484498,0.0007599623,0.0001532298,0.001515457],"genre_scores_gemma":[0.9969127,0.0007803956,0.0005777922,0.0001088215,0.00001538132,0.00001267697,0.000787681,0.00001530589,0.0007892578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001815592,"threshold_uncertainty_score":0.006073773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152801361297739,"score_gpt":0.2693202026248561,"score_spread":0.2477921890118787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}