{"id":"W4390063338","doi":"10.1016/j.bioorg.2023.107045","title":"Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy","year":2023,"lang":"en","type":"review","venue":"Bioorganic Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministry of Rural Affairs","keywords":"Cyclin-dependent kinase 2; Cyclin-dependent kinase; Cell cycle; Chemistry; Kinase; Cancer therapy; Cancer research; Cyclin; Cancer; Cell biology; Cell; Computational biology; Biochemistry; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006283976,0.001011669,0.001101575,0.001324828,0.0002422356,0.0009172042,0.0007602109,0.0006060428,0.002816779],"category_scores_gemma":[0.0005350385,0.000346806,0.0005077443,0.001415395,0.0005065628,0.000933003,0.0006496527,0.002261989,0.001473949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008194591,"about_ca_system_score_gemma":0.0008075717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008774005,"about_ca_topic_score_gemma":0.001990532,"domain_scores_codex":[0.9998449,0.00002758398,0.0000113824,0.00002765185,0.00005669762,0.00003176184],"domain_scores_gemma":[0.9998586,0.0000605899,0.00002122946,0.000007009164,0.00003323509,0.00001931781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002115793,0.0002094157,0.0001548951,0.01483513,0.0001365314,0.0002684974,0.000073792,0.001993103,0.01947392,0.01398575,0.03048046,0.9181769],"study_design_scores_gemma":[0.00006287115,0.0002257086,0.0003929181,0.001025711,0.0001245666,0.0006028592,0.00003071354,0.0005059551,0.008658406,0.003492857,0.9848488,0.0000285242],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005264968,0.9954711,0.0009185662,0.0002418013,0.0002176545,0.00001305319,0.00004368544,0.00002039769,0.002547318],"genre_scores_gemma":[0.003734088,0.9938968,0.0006639333,0.0002504463,0.0001220782,0.00001378195,0.00006328789,0.000003838899,0.001251897],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002816779,"threshold_uncertainty_score":0.009423018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1426312367355385,"score_gpt":0.4005453388482591,"score_spread":0.2579141021127206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}