{"id":"W4390081120","doi":"10.1016/j.jpeds.2023.113879","title":"Feasibility and Safety of Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia (SANE-01): A Randomized, Double-blind, Placebo-controlled Phase Ib Clinical Trial","year":2023,"lang":"en","type":"article","venue":"The Journal of Pediatrics","topic":"Neonatal and fetal brain pathology","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Heritage; GDI Integrated Facility Services (Canada); Centre Hospitalier Universitaire Sainte-Justine; Philips (Canada); McGill University; Université de Montréal; Ordre des Psychologues du Québec; McGill University Health Centre","funders":"","keywords":"Medicine; Sildenafil; Asphyxia; Placebo; Clinical trial; Double blind; Randomized controlled trial; Anesthesia; Internal medicine; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001821058,0.001558545,0.003695392,0.0003969158,0.0004669235,0.001561778,0.001106999,0.00289292,0.006584598],"category_scores_gemma":[0.001605749,0.0008481802,0.002101295,0.0003398886,0.001748737,0.001228652,0.0003735669,0.003994833,0.00115826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005264427,"about_ca_system_score_gemma":0.00113268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005490656,"about_ca_topic_score_gemma":0.001156439,"domain_scores_codex":[0.9994362,0.0002661269,0.00003884531,0.0001106138,0.00004351895,0.0001047678],"domain_scores_gemma":[0.9992009,0.0002785499,0.0001665639,0.0000730281,0.00004578794,0.0002353207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.97502,0.006730107,0.0002809363,0.0008685555,0.0007043644,0.00003538994,0.00004357208,0.0001864104,0.002570617,0.0001670183,0.0005611315,0.01283185],"study_design_scores_gemma":[0.9468123,0.05138321,0.0005531132,0.00004026642,0.0002792246,0.00001812744,0.00001850746,0.0001938052,0.000291392,0.00008831371,0.0003105638,0.0000111775],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790758,0.00985019,0.001040539,0.001249569,0.0008600182,0.003953002,0.0009747606,0.0001593811,0.002836592],"genre_scores_gemma":[0.9784937,0.007631933,0.002009684,0.001921328,0.0009767188,0.00456029,0.001023789,0.00003373518,0.003348941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006584598,"threshold_uncertainty_score":0.02202761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05798394698219199,"score_gpt":0.3846925209348367,"score_spread":0.3267085739526447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}