{"id":"W4390102572","doi":"10.1016/j.nucmedbio.2023.108872","title":"Evaluation of a novel hexadentate 1,2-hydroxypyridinone-based acyclic chelate, HOPO-O6-C4, for 43Sc/47Sc, 68Ga, and 45Ti radiopharmaceuticals","year":2023,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; TRIUMF","funders":"National Cancer Institute","keywords":"Chemistry; Biodistribution; In vivo; Chelation; Radiochemistry; In vitro; Nuclear chemistry; Combinatorial chemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660966,0.0002235943,0.0001643534,0.0001320747,0.0001558545,0.0002080745,0.0002885528,0.0002535798,0.001175047],"category_scores_gemma":[0.0001217104,0.00009452849,0.00009702321,0.0000943751,0.0001866042,0.0001520532,0.0002012506,0.0001469445,0.0002257637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002532677,"about_ca_system_score_gemma":0.0002822487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006054871,"about_ca_topic_score_gemma":0.000979661,"domain_scores_codex":[0.999936,0.00001454567,0.000004533721,0.00001539462,0.00001334475,0.0000161928],"domain_scores_gemma":[0.9999292,0.00001184836,0.00001862457,0.00000681342,0.00001354078,0.00001995343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006079944,0.00003926457,0.0001344311,0.0001672859,0.000007022324,0.00007587561,0.00004099569,0.0003301539,0.9925365,0.0002572345,0.0001093066,0.005693936],"study_design_scores_gemma":[0.00004160956,0.001220332,0.0004721688,0.000006350527,0.00002330315,0.000148128,0.00001862699,0.0006315727,0.9907341,0.00002623732,0.006668714,0.000008911666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906618,0.002029199,0.00378833,0.00007249079,0.00003263268,0.00008925044,0.0001992002,0.0001234508,0.00300361],"genre_scores_gemma":[0.9909511,0.0008720804,0.004929774,0.00005032951,0.000006497565,0.00003984202,0.0002647803,0.00002086998,0.00286477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001175047,"threshold_uncertainty_score":0.003930926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3240537327593066,"score_gpt":0.4831004309542614,"score_spread":0.1590466981949548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}