{"id":"W4390111802","doi":"10.1192/bjp.2023.148","title":"Features of immunometabolic depression as predictors of antidepressant treatment outcomes: pooled analysis of four clinical trials","year":2023,"lang":"en","type":"article","venue":"The British Journal of Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta; Dalhousie University","funders":"National Institute of Mental Health; Sixth Framework Programme; Otsuka Pharmaceutical; Otsuka Canada Pharmaceutical; Novo Nordisk; ZonMw; Laureate Institute for Brain Research, University of Tulsa; European Commission; ACADIA Pharmaceuticals; University of Oxford; Janssen Scientific Affairs; Neurocrine Biosciences; Brain and Behavior Research Foundation; Takeda Pharmaceuticals U.S.A.; Medical Research Council; Biogen; American Foundation for Suicide Prevention; H. Lundbeck A/S; Patient-Centered Outcomes Research Institute; Sage Therapeutics; GlaxoSmithKline","keywords":"Internal medicine; Medicine; Meta-analysis; Body mass index; Antidepressant; Depression (economics); Atypical depression; Clinical trial; Pooled analysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003055205,0.0001741921,0.00163167,0.000477654,0.0001304565,0.00004717118,0.00070312,0.0001150918,0.0001023446],"category_scores_gemma":[0.003372682,0.0001144329,0.0018287,0.001473274,0.0002836351,0.0001219507,0.00007883297,0.0002691094,0.000002422518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001007956,"about_ca_system_score_gemma":0.0002048245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002536137,"about_ca_topic_score_gemma":0.00009810215,"domain_scores_codex":[0.9950036,0.001550046,0.002311494,0.0002324857,0.0006750888,0.0002272545],"domain_scores_gemma":[0.9949277,0.001814415,0.002628116,0.0004092013,0.0001194783,0.0001010608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0018822,0.002959502,0.8346388,0.0001165,0.009221855,0.00009991453,0.0005950034,0.001205832,0.04347684,0.0004171722,0.005002037,0.1003844],"study_design_scores_gemma":[0.002852608,0.0004264429,0.9861977,0.0002189047,0.002300462,0.0001047594,0.0004397369,0.00002837523,0.006368028,0.0008737067,0.00009064533,0.00009863605],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926291,0.004656856,0.00002535593,0.0004480737,0.001461244,0.0002353675,0.000162172,0.00001651516,0.0003653122],"genre_scores_gemma":[0.9926404,0.006758896,0.0001292045,0.000106351,0.0001455278,0.000002848599,0.000003220433,0.0000188814,0.0001946784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.151559,"threshold_uncertainty_score":0.4666438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0643224984415734,"score_gpt":0.3782921966709784,"score_spread":0.313969698229405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}