{"id":"W4390113708","doi":"10.2217/frd-2023-0022","title":"Garadacimab for the prevention of hereditary angioedema attacks: a plain language summary of the VANGUARD study","year":2023,"lang":"en","type":"article","venue":"Future Rare Diseases","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Alberta; Ottawa Allergy Research Corporation; University of Ottawa","funders":"","keywords":"Hereditary angioedema; Vanguard; Placebo; Medicine; C1-inhibitor; Angioedema; Surgery; Internal medicine; Dermatology; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001865443,0.0001666824,0.0003311649,0.00007900564,0.0001458812,0.000008896199,0.0002106213,0.0000625908,0.00008329465],"category_scores_gemma":[0.0002001696,0.00009556542,0.0004767766,0.0004540836,0.00008180516,0.0000716224,0.00006154019,0.00006806744,0.000003384793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002207332,"about_ca_system_score_gemma":0.0001508589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006056518,"about_ca_topic_score_gemma":0.0001025501,"domain_scores_codex":[0.9987499,0.00008962445,0.0003395381,0.0002227979,0.0003935266,0.000204584],"domain_scores_gemma":[0.9987499,0.0003556863,0.0001838131,0.0005318316,0.0001112944,0.00006746377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002506182,0.002750863,0.5779334,0.002038319,0.001751227,0.0001353456,0.0180637,0.00014038,0.001161487,0.0003873998,0.3384897,0.0546421],"study_design_scores_gemma":[0.002275289,0.0004652275,0.955214,0.0003488704,0.001041421,0.00000940174,0.03433704,0.0002494337,0.0008284643,0.0001382026,0.004954498,0.0001381651],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757013,0.01897339,0.00003226911,0.001462026,0.0007947736,0.002131849,0.0006914242,0.0001075339,0.0001054806],"genre_scores_gemma":[0.9961283,0.00006943015,0.00003411773,0.0001270272,0.001183796,0.0001240751,0.0003262963,0.00003138456,0.001975603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3772807,"threshold_uncertainty_score":0.3897045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585118232168862,"score_gpt":0.2990552740792299,"score_spread":0.2832040917575413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}