{"id":"W4390114814","doi":"10.1093/bjd/ljad527","title":"Skin photoageing following sun exposure is associated with decreased epigenetic and biologic age, and correlates with basal cell carcinoma phenotype","year":2023,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; University of Toronto; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Cancer Research Society; Canadian Dermatology Foundation","keywords":"Epigenetics; Skin cancer; DNA methylation; Basal cell carcinoma; Basal (medicine); Biology; Phenotype; Sun exposure; Ageing; Pathology; Cancer; Basal cell; Medicine; Genetics; Dermatology; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002159723,0.0001669704,0.0001944982,0.00037087,0.0001552363,0.000397534,0.0001137424,0.0001767735,0.001553693],"category_scores_gemma":[0.0007657596,0.00008199803,0.0001739069,0.0003414521,0.0001301102,0.000164983,0.0002080411,0.00024436,0.0002443511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001087906,"about_ca_system_score_gemma":0.00007149642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008971299,"about_ca_topic_score_gemma":0.001244105,"domain_scores_codex":[0.999872,0.00002125219,0.000009009305,0.00005463182,0.00003110993,0.00001193634],"domain_scores_gemma":[0.9995198,0.00006616017,0.0002271884,0.00005590693,0.00007930337,0.0000515026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007761598,0.00004697184,0.9007537,0.0000803056,0.0001456744,0.0002283496,0.0002630125,0.0001715158,0.07978094,0.00005950507,0.0001364332,0.0175574],"study_design_scores_gemma":[0.000001386698,0.00009660111,0.9959574,0.00000313262,0.00002700566,0.0004160349,0.00006629667,0.000102379,0.00302225,0.00003768705,0.0002667822,0.000003009751],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973894,0.0006140733,0.001056983,0.00001824058,0.000008518386,0.0000107832,0.000370209,0.00002020503,0.0005116723],"genre_scores_gemma":[0.9988558,0.0001706965,0.000326659,0.00001070157,0.000004956329,0.000004152906,0.0002056444,0.000005043342,0.0004162299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553693,"threshold_uncertainty_score":0.005197585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007521355220395408,"score_gpt":0.2119444686350998,"score_spread":0.2044231134147044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}