{"id":"W4390115170","doi":"10.1093/cei/uxad135","title":"Gene expression analysis revealed downregulation of complement receptor 1 in clonal B cells in cold agglutinin disease","year":2023,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"Blood groups and transfusion","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Helse Sør-Øst RHF; Kreftforeningen","keywords":"Cold agglutinin disease; Downregulation and upregulation; Gene; Complement receptor; Biology; Complement (music); Agglutinin; Gene expression; Molecular biology; Genetics; Immunology; Complement system; Antibody; Lectin; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007756665,0.0001855701,0.0002160687,0.0005175144,0.00017723,0.0001967731,0.00008521419,0.0002457483,0.0007149946],"category_scores_gemma":[0.0001397071,0.00009378103,0.0002116483,0.0003838705,0.0001515269,0.0000657011,0.0001325037,0.0002263409,0.0001451442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001643332,"about_ca_system_score_gemma":0.00008963838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007294185,"about_ca_topic_score_gemma":0.0008098566,"domain_scores_codex":[0.999889,0.000008567797,0.000007999304,0.00003862503,0.0000283076,0.00002754053],"domain_scores_gemma":[0.99991,0.0000201705,0.00002740529,0.000006823902,0.00001478899,0.00002080447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001626309,0.000009736778,0.008462591,0.00002775764,0.00001197492,0.0002456822,0.00005300284,0.00003851537,0.9890655,0.00001458511,0.00003017969,0.001877756],"study_design_scores_gemma":[0.00002404912,0.0004941532,0.6688741,0.00001402457,0.0001152235,0.004293271,0.0002627875,0.00102117,0.3230082,0.0001245798,0.001754376,0.00001399218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989317,0.0003324863,0.0002970921,0.0000111432,0.000002454299,0.00000384674,0.000278648,0.00001212135,0.0001303818],"genre_scores_gemma":[0.9980896,0.0001881758,0.000760045,0.00003007493,0.000004632655,0.00001078675,0.0006024993,0.000005352523,0.0003087097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007294185,"threshold_uncertainty_score":0.002391875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04924431688269189,"score_gpt":0.3817033218037129,"score_spread":0.332459004921021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}