{"id":"W4390116519","doi":"10.1016/j.xgen.2023.100468","title":"Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas","year":2023,"lang":"en","type":"review","venue":"Cell Genomics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"NHLBI Division of Intramural Research; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; Kidney Research UK; National Human Genome Research Institute; National Heart and Lung Institute; Ministério da Saúde; Kaiser Foundation Research Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Fogarty International Center; Canadian Institutes of Health Research; Manchester Biomedical Research Centre; National Institute for Health and Care Research; National Eye Institute; San Diego State University; Fundación IMSS; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; University of North Carolina at Chapel Hill; Instituto Mexicano del Seguro Social; University of Minnesota; Financiadora de Estudos e Projetos; Conselho Nacional de Desenvolvimento Científico e Tecnológico; University of Toronto; Government of Ontario; Society for the Study of Addiction; Hankuk University of Foreign Studies; University of Manchester; National Institute of Neurological Disorders and Stroke; British Heart Foundation; Diabetes Research Connection; National Cancer Institute; Mississippi State Department of Health; Indiana Clinical and Translational Sciences Institute; National Institute of Dental and Craniofacial Research; Andrea and Charles Bronfman Philanthropies; Howard University; Ontario Research Foundation; University of Washington; University of Miami; Northwestern University; National Institute on Minority Health and Health Disparities; Jackson State University; National Center on Minority Health and Health Disparities; National Institute of Mental Health; University of Alabama at Birmingham; Office of Dietary Supplements; Office of the Director; U.S. Department of Health and Human Services","keywords":"Genome-wide association study; Biology; Genetic association; Genetics; Kidney disease; Population; Genome; Disease; Genomics; Computational biology; Gene; 1000 Genomes Project; Evolutionary biology; Genotype; Medicine; Single-nucleotide polymorphism; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002233313,0.000954764,0.002315481,0.001821931,0.0001726937,0.0009069424,0.001112738,0.001322513,0.001954642],"category_scores_gemma":[0.003292793,0.0003067913,0.001019739,0.001973908,0.0005023319,0.0007142836,0.0007091177,0.00178735,0.0009263963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007961866,"about_ca_system_score_gemma":0.001659362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002000332,"about_ca_topic_score_gemma":0.003092716,"domain_scores_codex":[0.9996138,0.0001275014,0.0000607309,0.0000938785,0.00007791528,0.00002618054],"domain_scores_gemma":[0.997937,0.001465163,0.0001475053,0.00004274654,0.0003041297,0.0001035958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0003309825,0.00004431261,0.002166507,0.01877605,0.001475183,0.0001988918,0.0000474839,0.0004054164,0.0004618181,0.00392703,0.02776214,0.9444042],"study_design_scores_gemma":[0.0002082492,0.0003944171,0.01867107,0.02109192,0.004010176,0.00261249,0.0001292462,0.0004644982,0.0006273851,0.009368127,0.9423212,0.0001012124],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.000105824,0.9988787,0.000122824,0.0004936886,0.0001290326,0.000002783998,0.00003408517,0.00000468606,0.0002285474],"genre_scores_gemma":[0.001056532,0.9979289,0.0001928028,0.0004003035,0.0001843679,0.000007730234,0.0000601457,0.00000212798,0.0001670569],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002315481,"threshold_uncertainty_score":0.01181102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04319828742506249,"score_gpt":0.280635327074432,"score_spread":0.2374370396493695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}