{"id":"W4390116519","doi":"10.1016/j.xgen.2023.100468","title":"Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas","year":2023,"lang":"en","type":"review","venue":"Cell Genomics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"NHLBI Division of Intramural Research; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; Kidney Research UK; National Human Genome Research Institute; National Heart and Lung Institute; Ministério da Saúde; Kaiser Foundation Research Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Fogarty International Center; Canadian Institutes of Health Research; Manchester Biomedical Research Centre; National Institute for Health and Care Research; National Eye Institute; San Diego State University; Fundación IMSS; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; University of North Carolina at Chapel Hill; Instituto Mexicano del Seguro Social; University of Minnesota; Financiadora de Estudos e Projetos; Conselho Nacional de Desenvolvimento Científico e Tecnológico; University of Toronto; Government of Ontario; Society for the Study of Addiction; Hankuk University of Foreign Studies; University of Manchester; National Institute of Neurological Disorders and Stroke; British Heart Foundation; Diabetes Research Connection; National Cancer Institute; Mississippi State Department of Health; Indiana Clinical and Translational Sciences Institute; National Institute of Dental and Craniofacial Research; Andrea and Charles Bronfman Philanthropies; Howard University; Ontario Research Foundation; University of Washington; University of Miami; Northwestern University; National Institute on Minority Health and Health Disparities; Jackson State University; National Center on Minority Health and Health Disparities; National Institute of Mental Health; University of Alabama at Birmingham; Office of Dietary Supplements; Office of the Director; U.S. Department of Health and Human Services","keywords":"Genome-wide association study; Biology; Genetic association; Genetics; Kidney disease; Population; Genome; Disease; Genomics; Computational biology; Gene; 1000 Genomes Project; Evolutionary biology; Genotype; Medicine; Single-nucleotide polymorphism; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005186914,0.000277338,0.0006969927,0.00005981516,0.0001585687,0.0000322808,0.0001247984,0.0002519435,0.000001017623],"category_scores_gemma":[0.0002127199,0.0001949453,0.0001033357,0.0001310259,0.0001599562,0.000002304987,0.0001205243,0.0001664391,0.000002185079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004518144,"about_ca_system_score_gemma":0.0002107668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009054341,"about_ca_topic_score_gemma":0.00007577912,"domain_scores_codex":[0.9984368,0.0003208554,0.0003848635,0.0005557955,0.00005284814,0.0002488318],"domain_scores_gemma":[0.9989104,0.0003510923,0.0003451275,0.0002707918,0.00002614843,0.00009643524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001267065,0.0007645857,0.4786618,0.01714144,0.008545803,0.00001642003,0.00958956,0.001403182,0.00989454,0.00001717939,0.006134299,0.4665641],"study_design_scores_gemma":[0.004549617,0.001759817,0.04112112,0.0005570755,0.003447245,0.00001461985,0.003076056,0.0006153745,0.00001621802,0.0001422946,0.9437723,0.0009282524],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2016134,0.7957741,0.0005187768,0.0000307187,0.000127366,0.001601053,0.0002973509,0.00001147679,0.00002572807],"genre_scores_gemma":[0.006568526,0.9901696,0.0009364527,0.00009141753,0.0003581101,0.0007013814,0.0008962704,0.00006918019,0.0002090131],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.937638,"threshold_uncertainty_score":0.794964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04319828742506249,"score_gpt":0.280635327074432,"score_spread":0.2374370396493695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}