{"id":"W4390122614","doi":"10.1212/nxi.0000000000200191","title":"CNS Inflammation as the First Sign of Complement Factor I Deficiency","year":2023,"lang":"en","type":"article","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Alexion Pharmaceuticals; Sanofi","keywords":"Medicine; Complement deficiency; Eculizumab; Inflammation; Immunology; Blockade; Complement system; Complement component 5; Internal medicine; Antibody; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000463517,0.0004433632,0.0005536268,0.0005995398,0.0007541556,0.0000309176,0.001068917,0.0002976476,0.0009443424],"category_scores_gemma":[0.0006785413,0.0003744758,0.0002403898,0.0008809215,0.0007674678,0.0002293156,0.0005352785,0.0006407513,0.003494182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002870727,"about_ca_system_score_gemma":0.0001133397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007464844,"about_ca_topic_score_gemma":0.00007101551,"domain_scores_codex":[0.9957638,0.001169067,0.001289841,0.0007495981,0.000191192,0.0008364601],"domain_scores_gemma":[0.996153,0.001562259,0.0008419854,0.001199735,0.000212015,0.00003098033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006886953,0.0001613834,0.02898185,0.0001204329,0.0001650343,0.00007146989,0.001200071,0.001124585,0.9444863,0.01171906,0.005941053,0.005340045],"study_design_scores_gemma":[0.002165471,0.001591609,0.8664772,0.0000255713,0.0001146387,0.000370987,0.0001417567,0.0002773105,0.04864273,0.001269488,0.07853844,0.0003848327],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815294,0.0002607884,0.00003746745,0.01301334,0.00218019,0.001456864,0.00006993613,0.0005963451,0.0008557098],"genre_scores_gemma":[0.9984668,0.0001310971,0.000003220156,0.0005745449,0.00006771966,0.0001952672,0.0002604434,0.00005658287,0.0002443061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8958436,"threshold_uncertainty_score":0.9999689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458383152584899,"score_gpt":0.2565551249789961,"score_spread":0.2319712934531472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}