{"id":"W4390127102","doi":"10.1016/j.jval.2023.09.062","title":"P47 How Do HTA Agencies Manage Uncertainties in the Long-Term Clinical Benefit of Gene Therapies? An Analysis of Recent Gene Therapy HTAs in England, Germany, France, Italy, Canada, and the United States","year":2023,"lang":"en","type":"article","venue":"Value in Health","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Term (time); Medicine; Political science; Physics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01217966,0.000166522,0.0008600631,0.002500871,0.001075411,0.007621686,0.0009104516,0.00192027,0.004967319],"category_scores_gemma":[0.06492744,0.0004380642,0.001181089,0.00540417,0.001920552,0.002816917,0.001398648,0.002812591,0.0002281166],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01275967,"about_ca_system_score_gemma":0.009904378,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3397641,"about_ca_topic_score_gemma":0.3284615,"domain_scores_codex":[0.9937011,0.002342688,0.0003108452,0.0003522972,0.001797618,0.00149553],"domain_scores_gemma":[0.9333612,0.04763513,0.009444878,0.0008566926,0.00611487,0.002587223],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001418313,0.0003365024,0.590096,0.0003972078,0.001454643,0.001029358,0.003740115,0.04519733,0.0004832516,0.1956813,0.03972601,0.1204401],"study_design_scores_gemma":[0.0003839985,0.0003986192,0.7913561,0.0009931595,0.0008707378,0.00055453,0.01330982,0.04715886,0.001004182,0.06848802,0.0752667,0.0002153074],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8152609,0.01467482,0.005464155,0.1135881,0.0001807419,0.0001741334,0.005485423,0.00006790782,0.04510372],"genre_scores_gemma":[0.9929638,0.001390332,0.0007635999,0.002465507,0.0001111321,0.00003345314,0.0004984397,0.0000156953,0.001757974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9878203,"threshold_uncertainty_score":0.675573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.322493166513005,"score_gpt":0.4149761842089676,"score_spread":0.09248301769596257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}