{"id":"W4390140141","doi":"10.1101/2023.12.21.572836","title":"Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Queen's University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Queen's University","keywords":"Mitochondrial fission; DNM1L; Toxicity; Pharmacology; GTPase; Internal medicine; Apoptosis; Pulmonary artery; Pulmonary hypertension; Endocrinology; Biology; Medicine; Chemistry; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000279084,0.0003560026,0.0005436915,0.0002654544,0.0001633751,0.0002591787,0.0003540817,0.0003608725,0.001116136],"category_scores_gemma":[0.0002394475,0.0001298453,0.0002607614,0.0001516378,0.0003059422,0.0003514892,0.0001272859,0.0009002073,0.0002730055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002061035,"about_ca_system_score_gemma":0.0003400779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000393099,"about_ca_topic_score_gemma":0.000880347,"domain_scores_codex":[0.999858,0.00004018189,0.00001489934,0.00002574055,0.00002556427,0.00003568103],"domain_scores_gemma":[0.9997899,0.00004511359,0.00006356086,0.00002542826,0.00001707327,0.00005900543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009817679,0.002622328,0.001433863,0.0003603429,0.00007897353,0.0001659894,0.00006722844,0.0005580566,0.951624,0.000231768,0.0003604582,0.03267922],"study_design_scores_gemma":[0.001921501,0.08830614,0.0156562,0.00003992085,0.0002733622,0.001076991,0.0000751832,0.001681143,0.8864098,0.00009000989,0.004440336,0.00002945694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949024,0.003111809,0.0004758779,0.0001084211,0.00002153832,0.00005813472,0.0003437367,0.00007311175,0.0009049064],"genre_scores_gemma":[0.995357,0.00207709,0.0009821801,0.00005247313,0.00003063076,0.0000762759,0.0005301362,0.00001065908,0.0008835975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001116136,"threshold_uncertainty_score":0.003733814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389389649352137,"score_gpt":0.2149202397584704,"score_spread":0.2010263432649491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}