{"id":"W4390143881","doi":"10.1002/mds.29691","title":"Embedding Patient Input in Outcome Measures for Long‐Term Disease‐Modifying Parkinson Disease Trials","year":2023,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"NIHR Cambridge Biomedical Research Centre; John Black Charitable Foundation; UK Dementia Research Institute; H. Lundbeck A/S; Moorfields Eye Hospital NHS Foundation Trust; Siemens Healthineers; Norges Forskningsråd; Novo Nordisk; Vetenskapsrådet; Eisai; HORIZON EUROPE Framework Programme; University of Bristol; Rosetrees Trust; Asthma and Lung UK; Wellcome Trust; University College London; Parkinson's UK; Voyager Therapeutics; Newcastle University; AstraZeneca; Barts Charity; Prothena; EU Joint Programme – Neurodegenerative Disease Research; European Association of Urology; Van Andel Research Institute; Apellis Pharmaceuticals; Health and Social Care Delivery Research; Michael J. Fox Foundation for Parkinson's Research; Boston Scientific Corporation; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Hjärnfonden; European Commission; Familjen Erling-Perssons Stiftelse; National Institute for Health and Care Research; Medical Research Council; Samsung Biomedical Research Institute; Teva Pharmaceutical Industries; Biogen; Programme Grants for Applied Research; CHDI Foundation; Research for Patient Benefit Programme; Alzheimer's Drug Discovery Foundation; Sanofi","keywords":"Physical therapy; Rating scale; Outcome (game theory); Disease; Movement disorders; Clinical trial; Parkinson's disease; Physical medicine and rehabilitation; Psychology; Clinical endpoint; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.6894344,0.002545512,0.005178366,0.005165844,0.001582031,0.012214,0.003938579,0.005991903,0.01152423],"category_scores_gemma":[0.777392,0.001731413,0.007085494,0.005844187,0.004257432,0.008202832,0.008028496,0.00849329,0.002476445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006106712,"about_ca_system_score_gemma":0.01745255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007328909,"about_ca_topic_score_gemma":0.001165422,"domain_scores_codex":[0.1339833,0.7983303,0.04505987,0.004136642,0.01754621,0.0009437008],"domain_scores_gemma":[0.1124875,0.7742686,0.03971963,0.03663442,0.03481387,0.002075991],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01889619,0.001459738,0.01431581,0.0866954,0.009752381,0.0002970457,0.005523306,0.01061958,0.00239266,0.06858056,0.03887627,0.7425911],"study_design_scores_gemma":[0.05241324,0.02093408,0.04247893,0.1454622,0.02001181,0.0006341396,0.002293288,0.02821392,0.01184735,0.2204485,0.4540222,0.001240412],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02768734,0.05904263,0.6169136,0.08631705,0.01326435,0.1337315,0.01345677,0.002089643,0.04749721],"genre_scores_gemma":[0.2435689,0.01054893,0.559175,0.02661788,0.004480805,0.1492752,0.003716467,0.0005173464,0.002099581],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.3105656,"threshold_uncertainty_score":0.3829827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08110814126479146,"score_gpt":0.3592909577564413,"score_spread":0.2781828164916499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}