{"id":"W4390143881","doi":"10.1002/mds.29691","title":"Embedding Patient Input in Outcome Measures for Long‐Term Disease‐Modifying Parkinson Disease Trials","year":2023,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"NIHR Cambridge Biomedical Research Centre; John Black Charitable Foundation; UK Dementia Research Institute; H. Lundbeck A/S; Moorfields Eye Hospital NHS Foundation Trust; Siemens Healthineers; Norges Forskningsråd; Novo Nordisk; Vetenskapsrådet; Eisai; HORIZON EUROPE Framework Programme; University of Bristol; Rosetrees Trust; Asthma and Lung UK; Wellcome Trust; University College London; Parkinson's UK; Voyager Therapeutics; Newcastle University; AstraZeneca; Barts Charity; Prothena; EU Joint Programme – Neurodegenerative Disease Research; European Association of Urology; Van Andel Research Institute; Apellis Pharmaceuticals; Health and Social Care Delivery Research; Michael J. Fox Foundation for Parkinson's Research; Boston Scientific Corporation; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Hjärnfonden; European Commission; Familjen Erling-Perssons Stiftelse; National Institute for Health and Care Research; Medical Research Council; Samsung Biomedical Research Institute; Teva Pharmaceutical Industries; Biogen; Programme Grants for Applied Research; CHDI Foundation; Research for Patient Benefit Programme; Alzheimer's Drug Discovery Foundation; Sanofi","keywords":"Physical therapy; Rating scale; Outcome (game theory); Disease; Movement disorders; Clinical trial; Parkinson's disease; Physical medicine and rehabilitation; Psychology; Clinical endpoint; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007022663,0.0004009148,0.0007172315,0.0004706117,0.000182718,0.00006395399,0.0001319559,0.00006644068,0.00008796466],"category_scores_gemma":[0.0006934221,0.0003455363,0.0005203564,0.0003902514,0.00003576059,0.000136838,0.00009524033,0.0001074851,0.00004508584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003257835,"about_ca_system_score_gemma":0.0001403558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005434195,"about_ca_topic_score_gemma":0.00007694773,"domain_scores_codex":[0.9969198,0.0001417894,0.000825737,0.0007053924,0.0006842866,0.0007230114],"domain_scores_gemma":[0.9984111,0.0001816376,0.0002222124,0.0004741434,0.00005129677,0.0006595769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00220318,0.001172617,0.9380946,0.000474214,0.0002832922,0.0002084182,0.000249638,0.000816347,0.000129445,0.0001682807,0.001030873,0.05516911],"study_design_scores_gemma":[0.008846207,0.0002526277,0.9690393,0.000347197,0.0005525725,6.37116e-8,0.0002716965,0.004708203,0.0001246688,0.009519068,0.005917619,0.0004207496],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891625,0.001423046,0.001908639,0.002569156,0.0005069866,0.003727245,0.0003444207,0.0002506787,0.0001073217],"genre_scores_gemma":[0.9942753,0.0004677997,0.0001432067,0.002177129,0.00008004106,0.001921863,0.0005622763,0.00007797744,0.0002943775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05474836,"threshold_uncertainty_score":0.9998997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08110814126479146,"score_gpt":0.3592909577564413,"score_spread":0.2781828164916499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}