{"id":"W4390144023","doi":"10.1101/2023.12.21.572541","title":"PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-κB-regulated immune response","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Oncolytics Biotech","keywords":"Oncolytic virus; Poly ADP ribose polymerase; PARP inhibitor; Cancer research; Biology; Immune system; Oncolytic adenovirus; Apoptosis; Melanoma; Immunology; Polymerase; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000158922,0.0002822912,0.0002445343,0.0001906759,0.0000797342,0.0002578857,0.0001574355,0.0002384742,0.002278721],"category_scores_gemma":[0.00009380608,0.0001001289,0.0003039898,0.0001513098,0.0001013076,0.000130662,0.0001370271,0.000480718,0.0004596563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000236931,"about_ca_system_score_gemma":0.0001348793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002779024,"about_ca_topic_score_gemma":0.0005168395,"domain_scores_codex":[0.9998741,0.00002193509,0.000014257,0.0000225008,0.00003423086,0.00003294424],"domain_scores_gemma":[0.9999381,0.00001488095,0.00001577289,0.000008831505,0.000008875207,0.00001364389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003489112,0.00009018782,0.00008557546,0.00005469949,0.000008711232,0.00002051237,0.000007013242,0.0001529651,0.9972855,0.00005294613,0.0000715756,0.001821406],"study_design_scores_gemma":[0.00004454995,0.0008930181,0.001235595,0.000004410041,0.00001203043,0.0001118042,0.00000817664,0.000674967,0.9956117,0.00002636101,0.001374764,0.000002699421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896691,0.002604204,0.003761664,0.0001181221,0.00005532333,0.0000969234,0.001083331,0.0001603856,0.00245089],"genre_scores_gemma":[0.993765,0.0006346483,0.002343228,0.00007042447,0.00000577786,0.00004289475,0.0008897047,0.00001430248,0.002233922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002278721,"threshold_uncertainty_score":0.007623076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04064149658688788,"score_gpt":0.2814832094479049,"score_spread":0.240841712861017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}