{"id":"W4390154684","doi":"10.1101/2023.12.22.573134","title":"Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chromatin; Epigenetics; Promoter; Enhancer; Biology; Androgen receptor; Gene expression; Transcription factor; Histone; Chromatin immunoprecipitation; Regulation of gene expression; Genetics; Gene; Cell biology; Prostate cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002507773,0.0002543671,0.0003080072,0.0003066541,0.0001425836,0.000401424,0.0003008133,0.0002189041,0.001003125],"category_scores_gemma":[0.0008211734,0.0001831302,0.0002695488,0.0003810577,0.0002874852,0.0004401091,0.0002331723,0.0002754303,0.0001981604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004774575,"about_ca_system_score_gemma":0.0003295508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002144308,"about_ca_topic_score_gemma":0.001954094,"domain_scores_codex":[0.9998788,0.00002132202,0.000004838466,0.00004932709,0.00003008285,0.00001560928],"domain_scores_gemma":[0.9998006,0.0000874148,0.00003557895,0.00003766026,0.0000242851,0.00001431953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000353678,0.0001025084,0.03035237,0.0003296575,0.0001156675,0.0001705418,0.00014413,0.4272091,0.4987848,0.01125597,0.001217402,0.0299643],"study_design_scores_gemma":[0.00001162539,0.00005025425,0.0202719,0.000007554469,0.00001720189,0.00004744315,0.0000370683,0.9065084,0.06591393,0.005731667,0.001381827,0.00002096868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8925955,0.0002707025,0.102097,0.0001040748,0.00001691852,0.00001740366,0.002865131,0.0007136497,0.001319674],"genre_scores_gemma":[0.9828012,0.0001434998,0.01417258,0.00001357099,0.000006872854,0.00002262044,0.002263556,0.00008834852,0.0004877603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002144308,"threshold_uncertainty_score":0.004263699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123495324756768,"score_gpt":0.2082477009594899,"score_spread":0.1970127477119222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}