{"id":"W4390174665","doi":"10.3390/genes15010027","title":"The Mutational Spectrum of Pre- and Post-Neoadjuvant Chemotherapy Triple-Negative Breast Cancers","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Jewish General Hospital; Fondation de l'Hôpital général juif; Fondation du cancer du sein du Québec; Université de Montréal; McGill University Health Centre; McGill University","keywords":"Chemotherapy; Triple-negative breast cancer; Cancer research; Biology; Exome sequencing; Breast cancer; Mutation; Gene; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007983256,0.00007222698,0.00007150689,0.00001869174,0.0000822982,0.00001478096,0.00008070117,0.00003803422,0.000007829174],"category_scores_gemma":[0.00003685456,0.00005594929,0.00003700743,0.00007042442,0.0001045079,0.000001252306,0.00004539651,0.00002339414,0.000002604043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001242063,"about_ca_system_score_gemma":0.0001391597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000241239,"about_ca_topic_score_gemma":0.0004556166,"domain_scores_codex":[0.999539,0.00001246586,0.0001064233,0.0001450067,0.00006922852,0.0001278855],"domain_scores_gemma":[0.9996775,0.00005039466,0.00005528555,0.000127647,0.00005651322,0.00003265164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001105952,0.00003872832,0.00562489,0.00003994608,0.000335646,0.000005614731,0.0008476602,0.001481239,0.8608057,0.001521506,0.01154816,0.1166449],"study_design_scores_gemma":[0.001737249,0.0004618429,0.4164588,0.00001519576,0.0000279595,0.00005200904,0.0009072723,0.0005853302,0.5522488,0.002088636,0.02513294,0.0002839549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959452,0.001960726,0.00004778038,0.001227229,0.0001767845,0.0001401719,0.0002649611,0.00000605281,0.0002311474],"genre_scores_gemma":[0.9931813,0.005531852,0.00009622591,0.0001834791,0.0002079394,0.00002048937,0.00007120684,0.00001282191,0.0006946728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4108339,"threshold_uncertainty_score":0.2281546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005006618799814047,"score_gpt":0.2392760920925573,"score_spread":0.2342694732927433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}