{"id":"W4390174857","doi":"10.3390/cancers16010095","title":"Extracellular Signal-Regulated Kinases: One Pathway, Multiple Fates","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; Cell biology; Cell fate determination; Cell growth; Kinase; Signal transduction; Context (archaeology); Extracellular; Biology; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141933,0.0001504679,0.0001388592,0.00005131236,0.0000891896,0.00001875256,0.0001709272,0.0001426515,0.0001122912],"category_scores_gemma":[0.00004797312,0.0001541951,0.00008893092,0.0001921347,0.00006808574,0.000003090696,0.00007609826,0.00006613139,0.0001472649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006825542,"about_ca_system_score_gemma":0.0002284271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001171323,"about_ca_topic_score_gemma":0.00007329395,"domain_scores_codex":[0.9989928,0.0000342348,0.000159266,0.0003555053,0.000123631,0.0003345748],"domain_scores_gemma":[0.9994389,0.00001556874,0.00005642481,0.0003209555,0.00005263881,0.0001155394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004525164,0.000009494116,0.0006963901,0.00002450481,0.00004587972,0.00002347514,0.00005268734,0.001081331,0.9878281,0.00009778007,0.006685725,0.003409402],"study_design_scores_gemma":[0.0005752327,0.0001908698,0.0008579198,0.0000233635,0.00001296665,0.000003620009,0.0001333116,0.001329206,0.8657075,0.00008567561,0.1308371,0.0002431996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957061,0.001973996,0.0004691065,0.00006087677,0.0002791445,0.0001971009,0.00007039885,0.00009430564,0.001148949],"genre_scores_gemma":[0.9930845,0.0001910142,0.0001266101,0.00008264914,0.0002876522,0.00005689454,0.0005300211,0.00003349862,0.005607173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1241514,"threshold_uncertainty_score":0.6287893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02111025626163523,"score_gpt":0.2285453586693193,"score_spread":0.207435102407684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}