{"id":"W4390174857","doi":"10.3390/cancers16010095","title":"Extracellular Signal-Regulated Kinases: One Pathway, Multiple Fates","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; Cell biology; Cell fate determination; Cell growth; Kinase; Signal transduction; Context (archaeology); Extracellular; Biology; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004174795,0.0009435279,0.001185101,0.0007683394,0.0004190719,0.002284562,0.0005378564,0.0008456236,0.002392855],"category_scores_gemma":[0.0003073921,0.0001858334,0.0004360633,0.0009214144,0.0006708544,0.00274259,0.0009027288,0.001901066,0.001285252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005331399,"about_ca_system_score_gemma":0.001093672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002323261,"about_ca_topic_score_gemma":0.0004833424,"domain_scores_codex":[0.999708,0.00005534638,0.00003533983,0.00005903031,0.0001026827,0.00003953406],"domain_scores_gemma":[0.9998437,0.00005804791,0.00002406541,0.000009875595,0.00003944775,0.00002480504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002920125,0.0001096935,0.0008037619,0.01394811,0.000234574,0.001315074,0.0005156911,0.0008189823,0.0359,0.05254085,0.04186886,0.8516524],"study_design_scores_gemma":[0.00001647096,0.000129341,0.0008255396,0.001542775,0.0001372673,0.00255958,0.0003111434,0.0001975233,0.005100175,0.01278611,0.9763654,0.00002855816],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002760105,0.9805504,0.002813691,0.003467978,0.00187238,0.00001816113,0.00008761567,0.00005044755,0.00837926],"genre_scores_gemma":[0.01246039,0.9773896,0.001546158,0.001276843,0.0009911601,0.00002138606,0.00008679248,0.00001226211,0.00621527],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002392855,"threshold_uncertainty_score":0.008004904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02111025626163523,"score_gpt":0.2285453586693193,"score_spread":0.207435102407684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}