{"id":"W4390192200","doi":"10.1002/alz.082453","title":"High VEGF‐A and low PlGF in plasma are associated with reduced longitudinal tau PET burden and slower cognitive decline in preclinical Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Internal medicine; Medicine; Cognitive decline; Oncology; Endocrinology; Hyperintensity; Atrophy; Pathogenesis; Disease; Dementia; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004794727,0.0004502634,0.0003314012,0.000386077,0.0002508979,0.0004082719,0.0001760314,0.0004057194,0.001618634],"category_scores_gemma":[0.001062204,0.0002491294,0.0003232321,0.0002810455,0.0002342495,0.000258818,0.0001863002,0.0005642411,0.0001540593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675072,"about_ca_system_score_gemma":0.0001735107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002089186,"about_ca_topic_score_gemma":0.001508478,"domain_scores_codex":[0.9998746,0.00003399527,0.00001201628,0.00004143264,0.00001957944,0.00001838971],"domain_scores_gemma":[0.9993668,0.0001276501,0.0002968917,0.00006053689,0.0000436253,0.0001044702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004858324,0.0002118163,0.9788045,0.00002940737,0.0002301166,0.0002534821,0.0001180716,0.0001222555,0.01201442,0.00004405568,0.000170577,0.003142934],"study_design_scores_gemma":[0.00001683034,0.0002394579,0.9985661,0.000002441055,0.00006182417,0.0002187509,0.00003985696,0.0002712546,0.0004547211,0.00004696835,0.00007911611,0.000002560396],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994631,0.000137504,0.0001105805,0.00002226737,0.000003693264,0.000002227449,0.0001353359,0.000005630116,0.0001196177],"genre_scores_gemma":[0.9994429,0.00003017562,0.0001291029,0.00001177962,0.00000709238,0.000004132209,0.0001373441,0.000001880337,0.0002355046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002089186,"threshold_uncertainty_score":0.005414844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06604546340084524,"score_gpt":0.3114809635989276,"score_spread":0.2454355001980824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}