{"id":"W4390192845","doi":"10.1002/alz.071534","title":"Outcome imbalance in clinical trials: Mitigating loss of statistical power","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Covariate; Placebo; Medicine; Statistical power; Clinical trial; Dementia; Internal medicine; Statistics; Mathematics; Pathology; Alternative medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4888169,0.002742839,0.004412639,0.004675066,0.001438957,0.004812412,0.004598737,0.004963173,0.005073861],"category_scores_gemma":[0.7097654,0.002292462,0.005100148,0.004326849,0.009233117,0.006149998,0.00702158,0.007427104,0.0008780198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003495842,"about_ca_system_score_gemma":0.005918142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007706533,"about_ca_topic_score_gemma":0.0008958021,"domain_scores_codex":[0.363799,0.57517,0.02711104,0.01457512,0.0176388,0.001705976],"domain_scores_gemma":[0.1955404,0.7344532,0.02739058,0.03289558,0.007858751,0.001861467],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0239827,0.001198702,0.07554721,0.01430304,0.0267699,0.001682448,0.005550637,0.1172598,0.006417114,0.1012752,0.02680135,0.599212],"study_design_scores_gemma":[0.01292368,0.0128814,0.03509208,0.007745792,0.008852145,0.00148402,0.0006705301,0.3141763,0.009984225,0.5486459,0.04700061,0.0005434122],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.04361971,0.01192566,0.9008402,0.01994024,0.001995062,0.01043624,0.0008034779,0.002138029,0.008301314],"genre_scores_gemma":[0.6742662,0.001415574,0.291202,0.01062297,0.001769917,0.01879697,0.0004004672,0.0004836074,0.001042356],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.5111831,"threshold_uncertainty_score":0.6303798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6570225338237523,"score_gpt":0.6211792348968838,"score_spread":0.03584329892686855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}