{"id":"W4390192922","doi":"10.1002/alz.074725","title":"Use of plasma P‐tau217 for enrichment in the Phase 2 PROSPECT‐ALZ study of LY3372689 in early symptomatic Alzheimer’s disease: Cohort selection and baseline characteristics","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Placebo; Cohort; Clinical endpoint; Randomization; Medicine; Internal medicine; Alzheimer's disease; Tau protein; Oncology; Disease; Cohort study; Clinical trial; Gerontology; Psychology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004329876,0.001338411,0.0009603552,0.0004700473,0.0007153241,0.0007067089,0.000612776,0.0007082688,0.001588007],"category_scores_gemma":[0.002195279,0.0004922971,0.0008090432,0.000511198,0.0005212851,0.0007244736,0.0004461117,0.0007782225,0.0004564497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005364564,"about_ca_system_score_gemma":0.00148303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001345295,"about_ca_topic_score_gemma":0.001937723,"domain_scores_codex":[0.9988208,0.0005639614,0.00005997323,0.0002504955,0.0001611387,0.0001436125],"domain_scores_gemma":[0.9989292,0.0001806889,0.0002274809,0.0001519936,0.0001905919,0.0003199684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5163495,0.01103352,0.4243235,0.0002869259,0.001604165,0.0007246446,0.0005284821,0.0006469355,0.01177356,0.0002734535,0.00230199,0.03015334],"study_design_scores_gemma":[0.06738415,0.1809557,0.735884,0.0000635362,0.002327026,0.001001292,0.0003237116,0.002066617,0.004026232,0.0005982748,0.005254205,0.0001153524],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963889,0.0004712817,0.0005305674,0.00006459444,0.00002447551,0.001353675,0.0007380175,0.00001220583,0.0004162719],"genre_scores_gemma":[0.9933201,0.0002239574,0.00120414,0.0001649926,0.00006417907,0.002550855,0.001650791,0.00001213889,0.0008088652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004329876,"threshold_uncertainty_score":0.02289885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05553064187282618,"score_gpt":0.344605204402286,"score_spread":0.2890745625294598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}