{"id":"W4390192937","doi":"10.1002/alz.076479","title":"Efforts toward discovering inhibitors of the SYK SH2–FCER1γ interaction as potential Alzheimer’s disease chemical probes and therapeutics","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"","keywords":"Syk; Drug discovery; Computational biology; Chemistry; Cancer research; Pharmacology; Biochemistry; Biology; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009911252,0.0007035449,0.0004665878,0.0006565217,0.000273387,0.0007080623,0.0005483925,0.0005391139,0.002403254],"category_scores_gemma":[0.0002981159,0.0002440429,0.0006439259,0.0003385046,0.0003133863,0.0006532026,0.0004913613,0.001243659,0.0008855386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007186672,"about_ca_system_score_gemma":0.0005590578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004246698,"about_ca_topic_score_gemma":0.0007086695,"domain_scores_codex":[0.9997111,0.00005764799,0.00001540444,0.00005356591,0.0001081195,0.00005418978],"domain_scores_gemma":[0.9998092,0.00002864468,0.00004657092,0.00001890137,0.00006583242,0.00003086057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002545671,0.0004259929,0.0007625893,0.0008778801,0.0001080426,0.0002536878,0.00008112341,0.001401294,0.9428018,0.005000968,0.003890309,0.04414185],"study_design_scores_gemma":[0.0001760994,0.00189518,0.001425444,0.00008726654,0.0001780689,0.0006250718,0.00006264245,0.004553813,0.9226843,0.001333119,0.06694858,0.00003037216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.610998,0.1585838,0.1714792,0.01064395,0.001024041,0.001550291,0.002541436,0.001956944,0.04122237],"genre_scores_gemma":[0.8410792,0.06662388,0.05951404,0.004112221,0.0003268394,0.0008332697,0.002162918,0.0001239606,0.02522376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002403254,"threshold_uncertainty_score":0.008039713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04244601932778361,"score_gpt":0.312968917600658,"score_spread":0.2705228982728743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}