{"id":"W4390192945","doi":"10.1002/alz.074194","title":"Characterization of Novel Antioxidant VANL‐100 on Akt and GSK3B Protein Activity and Expression","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Protein kinase B; GSK3B; GSK-3; Phosphorylation; Chemistry; PI3K/AKT/mTOR pathway; Pharmacology; Signal transduction; Antioxidant; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007235825,0.0002342622,0.0002084575,0.0002423382,0.00009627605,0.0001743783,0.0001425875,0.0001699103,0.001299369],"category_scores_gemma":[0.00009474417,0.0001044581,0.0001909539,0.0001719782,0.0001126904,0.0001083047,0.0001018905,0.0002237711,0.0002522543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001778525,"about_ca_system_score_gemma":0.0001186019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003294047,"about_ca_topic_score_gemma":0.0006533699,"domain_scores_codex":[0.999956,0.000006709625,0.000004343216,0.00001129858,0.00001289281,0.000008861149],"domain_scores_gemma":[0.9999458,0.00001206995,0.00001324558,0.000005558001,0.00001112895,0.00001230659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001247121,0.00003342959,0.0001588354,0.00003823187,0.000006583884,0.00002068975,0.000004568946,0.0000602037,0.9976135,0.00002343725,0.00002039677,0.001895319],"study_design_scores_gemma":[0.00003596248,0.0005149491,0.003002683,0.000008077937,0.00002883764,0.0001242633,0.00001616645,0.0005458404,0.9929598,0.00002630353,0.002733907,0.000003123728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932891,0.003223636,0.001844573,0.00006841902,0.00001481735,0.00003393227,0.0003355645,0.00003962947,0.001150374],"genre_scores_gemma":[0.9927766,0.001396167,0.002196597,0.00006796807,0.000008725478,0.00005368585,0.0008849541,0.00001358709,0.002601677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299369,"threshold_uncertainty_score":0.004346848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02724338086867161,"score_gpt":0.2855962640985198,"score_spread":0.2583528832298482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}