{"id":"W4390192945","doi":"10.1002/alz.074194","title":"Characterization of Novel Antioxidant VANL‐100 on Akt and GSK3B Protein Activity and Expression","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Protein kinase B; GSK3B; GSK-3; Phosphorylation; Chemistry; PI3K/AKT/mTOR pathway; Pharmacology; Signal transduction; Antioxidant; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163521,0.0001065901,0.0001077924,0.0000403978,0.0000691992,0.00001280313,0.00006439632,0.00007767008,0.000004855538],"category_scores_gemma":[0.00003727594,0.00008979796,0.00002419742,0.000085669,0.0001108234,0.000006483917,0.0002767691,0.00005773225,0.000002268457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":8.049722e-7,"about_ca_system_score_gemma":0.00001165398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009378586,"about_ca_topic_score_gemma":0.00000201083,"domain_scores_codex":[0.9992889,0.00002827075,0.0001072647,0.0002756324,0.000133633,0.0001663561],"domain_scores_gemma":[0.9996825,0.000008087167,0.00006203511,0.0001528075,0.00004443192,0.0000501489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008851769,0.00009745214,0.0004972473,0.00001532102,0.0005060769,6.318792e-7,0.00001865939,1.813894e-7,0.9943353,0.00001499935,0.0001132064,0.004312394],"study_design_scores_gemma":[0.0003428167,0.0002395526,0.02715841,0.00002729504,0.0001320286,8.554231e-7,0.000008154162,0.00003416176,0.971051,0.00000904989,0.0009019425,0.00009469962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973035,0.001896995,0.0001738359,0.0002343595,0.00002690983,0.0002648286,0.00003241746,0.00001263894,0.00005450555],"genre_scores_gemma":[0.9991931,0.0003452753,0.0002612142,0.0000308971,0.00004353838,0.00003888716,0.00005816453,0.00001160528,0.00001731313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02666116,"threshold_uncertainty_score":0.3661854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02724338086867161,"score_gpt":0.2855962640985198,"score_spread":0.2583528832298482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}