{"id":"W4390192976","doi":"10.1002/alz.079161","title":"Blood‐based biomarkers for predicting treatment response in the Apathy in Dementia Methylphenidate Trial 2 randomized clinical trial","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Apathy; Placebo; Internal medicine; Medicine; Methylphenidate; Biomarker; Randomized controlled trial; Confidence interval; Psychology; Attention deficit hyperactivity disorder; Psychiatry; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003593087,0.001828853,0.00368354,0.0004021117,0.0004084944,0.001095336,0.0009584146,0.002111523,0.005036952],"category_scores_gemma":[0.004656462,0.000534447,0.002137329,0.0004431804,0.0005891142,0.001170115,0.0004672931,0.002778813,0.0004941754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005827028,"about_ca_system_score_gemma":0.001017816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007925564,"about_ca_topic_score_gemma":0.001389418,"domain_scores_codex":[0.9983038,0.00108421,0.0001274816,0.0002391314,0.0001180578,0.0001273006],"domain_scores_gemma":[0.9976338,0.0008615396,0.0007268616,0.0001314019,0.0002193945,0.0004269525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9794366,0.002283177,0.006342207,0.0006767643,0.002400462,0.00003262797,0.00002650516,0.0002876948,0.0004822679,0.00008718634,0.0006592534,0.007285331],"study_design_scores_gemma":[0.9313987,0.03680908,0.02298046,0.0001626077,0.00364715,0.00006111016,0.00003082359,0.002631373,0.0004561101,0.0006728792,0.001108122,0.00004148353],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975899,0.01157036,0.0009098021,0.001471275,0.0006687936,0.003999868,0.003126346,0.0001135425,0.002240995],"genre_scores_gemma":[0.9830077,0.002146956,0.001877163,0.001007978,0.0005803488,0.007068177,0.002143722,0.00001456,0.002153442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005036952,"threshold_uncertainty_score":0.01900226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1066935709475635,"score_gpt":0.4205427374070893,"score_spread":0.3138491664595257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}