{"id":"W4390193045","doi":"10.1002/alz.079734","title":"Selective targeting and protection against toxic amyloid‐beta oligomers by PMN310, a monoclonal antibody rationally designed for greater therapeutic potency in Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amorfix (Canada); University of British Columbia","funders":"","keywords":"In vivo; Monoclonal antibody; Antibody; Epitope; Chemistry; Potency; Thioflavin; In vitro; Amyloid (mycology); Amyloid beta; Pharmacology; Biochemistry; Peptide; Molecular biology; Alzheimer's disease; Biology; Immunology; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002305476,0.0003761266,0.0002271343,0.0001862572,0.00009346651,0.000185081,0.0002247181,0.0002456124,0.0004566337],"category_scores_gemma":[0.000167259,0.0001232513,0.000138009,0.00009680667,0.0001469229,0.0002090999,0.0001280325,0.0003465741,0.00017411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998532,"about_ca_system_score_gemma":0.0002714694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004807358,"about_ca_topic_score_gemma":0.0004619105,"domain_scores_codex":[0.9999264,0.00001237858,0.000005185172,0.00001469405,0.00002337583,0.00001794272],"domain_scores_gemma":[0.9999423,0.000009497551,0.00001643134,0.000004623416,0.0000128648,0.00001426034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002294606,0.00007917464,0.000222922,0.0000417126,0.000005870574,0.00006582701,0.000008909772,0.0007083963,0.9936562,0.0001463867,0.00008787509,0.004747141],"study_design_scores_gemma":[0.0001799505,0.001809914,0.002163144,0.000009610654,0.00003374675,0.0005267372,0.00001048157,0.0052503,0.9876193,0.0001629921,0.002225989,0.000007849188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991066,0.001466879,0.005749793,0.00009871907,0.00002002667,0.00008022835,0.0001006396,0.00006447414,0.001353178],"genre_scores_gemma":[0.9916196,0.0008260509,0.006227253,0.00008101934,0.000007615908,0.00003446432,0.000124964,0.000008581877,0.001070359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004807358,"threshold_uncertainty_score":0.002175629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03883393591161882,"score_gpt":0.3159998919099116,"score_spread":0.2771659559982928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}