{"id":"W4390194331","doi":"10.1002/alz.078421","title":"Astrocyte reactivity potentiates longitudinal tau tangle accumulation in cognitively unimpaired individuals","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University","funders":"","keywords":"Astrocyte; Glial fibrillary acidic protein; Psychology; Cohort; Pathology; Longitudinal study; Neuroscience; Medicine; Internal medicine; Central nervous system; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003413307,0.0003276293,0.0002863289,0.000974976,0.0005104129,0.0005146499,0.0002084361,0.0003257745,0.001167684],"category_scores_gemma":[0.00132133,0.0002475334,0.0002364242,0.0004777013,0.0002595999,0.0002334628,0.0003721746,0.0003306362,0.0002282253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002012828,"about_ca_system_score_gemma":0.000162837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004540149,"about_ca_topic_score_gemma":0.005316104,"domain_scores_codex":[0.9998573,0.00002886272,0.00001353877,0.00004381419,0.0000290701,0.00002737354],"domain_scores_gemma":[0.9991277,0.0001005279,0.0003986434,0.0001026298,0.000153168,0.0001173405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009315616,0.0001293522,0.9791374,0.00002726163,0.00007260276,0.0007089148,0.0003613935,0.0001243957,0.01388615,0.00005602639,0.0001420019,0.004422941],"study_design_scores_gemma":[0.000003163536,0.000170822,0.9981796,0.000003108929,0.00002044085,0.000576798,0.00009507342,0.000135651,0.0007025708,0.00005270058,0.00005763872,0.000002467817],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996606,0.0000585332,0.00005989294,0.000005901104,0.000001679436,0.000002611898,0.00004542869,0.000005098518,0.0001603006],"genre_scores_gemma":[0.9997686,0.0000240044,0.00006155612,0.000004510761,0.000002126161,0.000002299275,0.00004435548,0.000001393042,0.00009112167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004540149,"threshold_uncertainty_score":0.009027421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0937583296743351,"score_gpt":0.3582911715006954,"score_spread":0.2645328418263603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}